TITLE

Clinical effects of leukofiltration and surface modification on postcardiopulmonary bypass atrial fibrillation in different risk cohorts

AUTHOR(S)
Gunaydin, Serdar; Ayrancioglu, Kamil; Dikmen, Erkan; McCusker, Kevin; Vijay, Venkataramana; Sari, Tamer; Tezcaner, Tevfik; Zorlutuna, Yaman
PUB. DATE
July 2007
SOURCE
Perfusion;Jul2007, Vol. 22 Issue 4, p279
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective. A manifestation of inflammatory injury to the heart, atrial fibrillation (AF), ranks among the most frequent and potentially life-threatening post-operative complications. Methods. In a prospective randomized study, 120 patients undergoing CABG were allocated into two groups (N = 60): Group 1- Polymethoxyethylacry latecoated circuits + Leukocyte filters (Terumo,USA); Group 2: Control:Uncoated circuits (Terumo,USA). Each group was further divided into three subgroups (N = 20) with respect to low (Euroscore 0-2), medium (3-5) and high (6+) risk patients. Results. Serum IL-2 levels were significantly lower in the study group at T4 and T5 (p < 0.01). C3a levels showed significant differences in the leukofiltrated group at T4 and T5 (p < 0.05). CPKMB levels demonstrated well-preserved myocardium in the leukofiltration group, post-operatively. AF incidence was 10% (2 patients) in the study and 35% (7 patients) in the control cohorts (p < 0.05). Phagocytic capacity on fibers in filtered patients was significantly lower. Conclusion: Leukofiltration and coating significantly reduce the incidence, ventricular rate, and duration of AF after CABG via modulation of systemic inflammatory response and platelet preservation in high risk groups.
ACCESSION #
27464233

 

Related Articles

  • Timing of leukocyte filtration during cardiopulmonary bypass. Matheis, G.; Scholz, M.; Simon, A.; Henrich, D.; Wimmer-Greinecker, G.; Moritz, A. // Perfusion;Mar2001 Supplement 1, Vol. 16, p31 

    The effects of leukocyte filtration on the outcome of cardiac surgery with cardiopulmonary bypass (CPB) have been shown by numerous investigators. In the majority of cases a leukocyte filter is placed in the arterial line instead of a standard arterial line filter and used throughout CPB....

  • The effects of leucodepletion in patients who develop the systemic inflammatory response syndrome following cardiopulmonary bypass. Treacher, D.; Sabbato, M.; Brown, K.; Gant, V. // Perfusion;Mar2001 Supplement 1, Vol. 16, p67 

    The development of the systemic inflammatory response syndrome (SIRS) is associated with increased morbidity and mortality. Numerous anticytokine trials have failed to demonstrate any outcome benefit and there has been little evidence of improvement in the prognosis of this condition over the...

  • Systemic leukocyte filtration during cardiopulmonary bypass. Fabbri, A.; Manfredi, J.; Piccin, C.; Soffiati, G.; Carta, M.; Gasparotto, E.; Nardon, G. // Perfusion;Mar2001 Supplement 1, Vol. 16, p11 

    Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to postoperative lung dysfunction. Activated leukocytes may play a role in the pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function after the use of leukocyte-depleting filters incorporated...

  • The effect of priming techniques of ultrafiltrators on blood rheology: an in vitro evaluation. Glogowski, K.R.; Stammers, A.H.; Niimi, K.S.; Tremain, K.D.; Muhle, M.L.; Trowbridge, C.C. // Perfusion;May2001, Vol. 16 Issue 3, p221 

    The increased interest of using ultrafiltration during cardiopulmonary bypass (CPB) has mandated a re-evaluation of the hematological effects of this blood conservation process. 'Rinse-free' ultrafiltrators can be primed using either crystalloid or blood prior to use. It is unknown whether one...

  • The inflammatory response to CPB: the role of leukocyte filtration. Asimakopoulos, George // Perfusion;May2002 Supplement 1, Vol. 17, p7 

    Examines the role of leukocyte filtration on the inflammatory response to cardiopulmonary bypass (CPB). Reduction of leukocyte activation and deleterious effects on organ function following cardiac surgery; Controversy on the efficacy of CPB in attenuating the effects of inflammatory response;...

  • Hemofiltration during cardiopulmonary bypass. Journois, Didier // Kidney International Supplement;May1998, Issue 66, pS-174 

    Investigates the effects of hemofiltration on cardiopulmonary bypass. Occurrence of postoperative organ dysfunctions; Reduction of postoperative blood loss; Improvement of hemodynamics.

  • POST-OPERATIVE ATRIAL FIBRILLATION; INCIDENCE AFTER CORONARY ARTERY BYPASS GRAFT SURGERY. Hussain, Ghulam; Ahmad, Naseem; Zaheer, Sara; Raza Baig, Mirza Ahmad // Professional Medical Journal;2015, Vol. 22 Issue 11, p1438 

    Atrial fibrillation is the most common arrhythmia observed following Coronary Artery Bypass Graft surgery. Objectives: To determine the incidence of post-operative atrial fibrillation in patients undergoing coronary artery bypass grafting. Materials and Methods: Study Design: Non-randomized...

  • Intraoperative treatment strategy to reduce the incidence of postcardiopulmonary bypass atrial fibrillation. Olivencia-Yurvati, AH; Wallace, WE; Wallace, N; Dimitrijevich, D; Knust, JK; Haas, L; Raven, PB // Perfusion;May2002 Supplement 1, Vol. 17, p35 

    Purpose: Postcardiopulmonary bypass atrial fibrillation remains a constant complication associated with coronary revascularization, the incidence of which occurs from 20% to 35%. Previous studies have addressed this problem in the postoperative setting utilizing pharmacological agents, but the...

  • Surgical treatment of chronic atrial fibrillation combined with rheumatic mitral valve disease: effects of the cryo-maze procedure and predictors for late recurrence. Baek, Man-Jong; Na, Chan-Young; Oh, Sam-Se; Lee, Chang-Ha; Kim, Jae Hyun; Seo, Hong Joo; Park, Sang-Won; Kim, Wook Sung // European Journal of Cardio-Thoracic Surgery;Nov2006, Vol. 30 Issue 5, p728 

    Abstract: Objective: The aim of this study was to evaluate the effects of the modified maze procedure using cryoablation for treating chronic atrial fibrillation (AF) associated with rheumatic mitral valve disease and to assess the risk factors for late failure of sinus rhythm restoration....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics