Downgrading in paediatric astrocytomas - prediction using molecular markers

Kaushik, Sil; Sandip, Chatterjee
July 2007
Journal of Pediatric Neurosciences;Jul-Dec2007, Vol. 2 Issue 2, p100
Academic Journal
Some paediatric astrocytomas appear to be low grade in WHO classification on classical histology although at surgery they may have been vascular and often difficult to resect to any degree of completeness. However these tumours often recur after a few years as a more aggressive tomour with WHO Grade 3 or 4 with a much worse prognosis. We report on 5 of our paediatric patients who had Grade 2 astrocytomas which downgraded to Grade 4 tumours when they recurred in 2-3 years. It has been our practice to routinely record p53 mutations as well as EGFR receptor changes and also PCNA(proliferating cell nuclear antigen) in all our patients with astrocytomas. We report how it may have been possible to predict future change in behaviour by noting the molecular markers in all 5 our patients that had this alteration in tumour biology.


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