Van Mourik, Orli
December 2007
Discover;Dec2007, Vol. 28 Issue 12, p19
The article offers information about the mental disorder schizophrenia and why the genes associated with this disease persist through generations. A study found that a gene known as disrupted-in-schizophrenia 1 may be responsible for the resilience of the disease because of its ability to tamper with brain functions in the hippocampus.


Related Articles

  • Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Chakos, Miranda H.; Schobel, Scott A.; Hongbin Gu; Gerig, Guido; Bradford, Daniel; Charles, Cecil; Lieberman, Jeffrey A.; Gu, Hongbin // British Journal of Psychiatry;Jan2005, Vol. 186, p26 

    Background: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known.Aims: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal...

  • Quantitative Brain Measurements in Chronic Schizophrenia. Rosenthal, Randall // British Journal of Psychiatry;Jan72, Vol. 120 Issue 554, p98 

    An abstract of the article "Quantitative Brain Measurements in Chronic Schizophrenia," by Randall Rosenthal and Llewellyn is presented. The study examines the brain specimens of ten chronic schizophrenic patients and ten clinically matched controls, in regard to the volume of the thalamus,...

  • Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Benetti, Stefania; Mechelli, Andrea; Picchioni, Marco; Broome, Matthew; Williams, Steven; McGuire, Philip // Brain: A Journal of Neurology;Sep2009, Vol. 132 Issue 9, p2426 

    Recent neuroimaging studies have reported deficits in functional integration between prefrontal cortex and the hippocampal formation in schizophrenia. It is unclear whether these alterations are a consequence of chronic illness or its treatment, and whether they are also evident in non-psychotic...

  • Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies. Kraguljac, Nina V.; Srivastava, Annusha; Lahti, Adrienne C. // Behavioral Sciences (2076-328X);Sep2013, Vol. 3 Issue 3, p330 

    Schizophrenia is a complex chronic mental illness that is characterized by positive, negative and cognitive symptoms. Cognitive deficits are most predictive of long-term outcomes, with abnormalities in memory being the most robust finding. The advent of functional magnetic resonance imaging...

  • Psychiatric disorders: DISC1 drives development through girdin. Whalley, Katherine // Nature Reviews Neuroscience;Nov2009, Vol. 10 Issue 11, p763 

    The article discusses a study on the role of girdin, an actin-binding protein in disrupted in schizophrenia 1's (DISC1) regulation of neuronal growth and migration in the postnatal and adult hippocampus. Mutations in DISC1 are considered a risk factor for multiple psychiatric and mental...

  • Depression gene in action. Qiu, Jane // Nature Reviews Neuroscience;Nov2006, Vol. 7 Issue 11, p835 

    The article reports the occurrence of psychiatric disorders by the interactions between genes and the environment. It also focuses on a multimodal imaging study that shows the various effects on brain function depending upon the individual stress by serotonin transporter gene (5-HTT) variants....

  • Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Sandner, Guy; Angst, Marie-Josée; Guiberteau, Thierry; Guignard, Blandine; Nehlig, Astrid // Frontiers in Behavioral Neuroscience;Jan2014, Vol. 8, p1 

    Rats with a neonatal ventral hippocampal lesion (NVHL) are used to model schizophrenia. They show enhanced locomotion and difficulties in learning after puberty. Such behavioral modifications are strengthened by dopaminergic psychostimulant drugs, which is also relevant for schizophrenia because...

  • Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease. Yakel, Jerrel // Pflugers Archiv European Journal of Physiology;Apr2013, Vol. 465 Issue 4, p441 

    The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability throughout the nervous system by acting on both the cys-loop ligand-gated nicotinic ACh receptor channels (nAChRs) and the G protein-coupled muscarinic ACh receptors (mAChRs). The hippocampus is an important area in the...

  • Alien Hand Syndrome: Neural Correlates of Movements without Conscious Will. Schaefer, Michael; Heinze, Hans-Jochen; Galazky, Imke // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    Background: The alien hand syndrome is a striking phenomenon characterized by purposeful and autonomous movements that are not voluntarily initiated. This study aimed to examine neural correlates of this rare neurological disorder in a patient with corticobasal degeneration and alien hand...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics