TITLE

IgA anticardiolipin antibody is associated with the extent of daily-life ischaemia in patients with chronic coronary artery disease

AUTHOR(S)
Ikonomidis, Ignatios; Lekakis, John; Vamvakou, Georgia; Loizou, Sozos; Revela, Ioanna; Andreotti, Felicita; Kremastinos, Dimitrios T.; Nihoyannopoulos, Petros
PUB. DATE
November 2007
SOURCE
Heart;Nov2007, Vol. 93 Issue 11, p1412
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Circulating anticardiolipin antibodies (aCL) may cause endothelial dysfunction. We investigated whether aCL are related to platelet activation, thrombin generation and daily-life ischaemia in patients with chronic coronary artery disease (CAD). Methods: We measured (medians 25th-75th percentile) IgG, IgM, IgA aCL serum levels (Arbitrary Elisa Units, AEU), prothrombin fragments (F1+2, nmol/l), 24 h urine excretion of 11-dehydrothromboxane B2 (11- DHTXB2, ng/mg creatinine) creatine kinase (CK) and its cardiac isoenzyme CK-MB (IU/l) in 60 patients with angiographically documented CAD and in 40 age and sex matched controls. Patients underwent a 48 h Holter monitoring for assessment of the number and duration of ischaemic episodes. Results: Patients had higher IgA-aCL levels than controls (3.2 vs 2.4 AEU, p=0.002). Increased IgA-ACA levels were related to increased number and duration of ischaemic episodes (p<0.01). By ANOVA, patients with ⩾10 ischaemic episodes (3rd tertile) or duration of ischaemia ⩾32min (3rd tertile) had higher IgA-aCL than those with lower ischaemic burden (4.95 vs 3 vs 2.5 AEU, p = 0.002 and 4.9 vs 3 vs 2.5 AEU, p = 0.001 respectively). Patients with ⩾2 ischaemic episodes (2nd and 3rd tertile) had higher 11-DHTXB2, than those with minimal ischaemia (2
ACCESSION #
27441273

 

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