IgA anticardiolipin antibody is associated with the extent of daily-life ischaemia in patients with chronic coronary artery disease

Ikonomidis, Ignatios; Lekakis, John; Vamvakou, Georgia; Loizou, Sozos; Revela, Ioanna; Andreotti, Felicita; Kremastinos, Dimitrios T.; Nihoyannopoulos, Petros
November 2007
Heart;Nov2007, Vol. 93 Issue 11, p1412
Academic Journal
Background: Circulating anticardiolipin antibodies (aCL) may cause endothelial dysfunction. We investigated whether aCL are related to platelet activation, thrombin generation and daily-life ischaemia in patients with chronic coronary artery disease (CAD). Methods: We measured (medians 25th-75th percentile) IgG, IgM, IgA aCL serum levels (Arbitrary Elisa Units, AEU), prothrombin fragments (F1+2, nmol/l), 24 h urine excretion of 11-dehydrothromboxane B2 (11- DHTXB2, ng/mg creatinine) creatine kinase (CK) and its cardiac isoenzyme CK-MB (IU/l) in 60 patients with angiographically documented CAD and in 40 age and sex matched controls. Patients underwent a 48 h Holter monitoring for assessment of the number and duration of ischaemic episodes. Results: Patients had higher IgA-aCL levels than controls (3.2 vs 2.4 AEU, p=0.002). Increased IgA-ACA levels were related to increased number and duration of ischaemic episodes (p<0.01). By ANOVA, patients with ⩾10 ischaemic episodes (3rd tertile) or duration of ischaemia ⩾32min (3rd tertile) had higher IgA-aCL than those with lower ischaemic burden (4.95 vs 3 vs 2.5 AEU, p = 0.002 and 4.9 vs 3 vs 2.5 AEU, p = 0.001 respectively). Patients with ⩾2 ischaemic episodes (2nd and 3rd tertile) had higher 11-DHTXB2, than those with minimal ischaemia (2


Related Articles

  • Quantitative Coronary Arteriography and Its Assessment of Atherosclerosis Part I. Examining the Independent Variables. Fleming, Richard M.; Harrington, Gordon M.; Gibbs, Harry R.; Swafford, Joseph // Angiology;Oct1994, Vol. 45 Issue 10, p829 

    Background. Previous work has demonstrated that quantitative coronary arteriography (QCA) can accurately measure phantom images to within ±0.1 mm and has been accepted as a reliable and reproducible method of measuring human coronary artery disease (CAD). Assessment of CAD by QCA involves the...

  • The effectiveness, side effects and acceptability of locally available brand of Clopidogrel (Osvix) as anti platelet tablet in CABG patients. Imani, Behzad; Safi-Ariyan, Reza; Manaafi, Babak; Karampourian, Arezo; Sani, Karim Ghazikhanlou // Tehran University Medical Journal;Jul2014, Vol. 72 Issue 4, p1 

    Background: Platelet activation and aggregation plays an essential role in the formation of coronary artery thrombosis. Nowadays, the Clopidogrel is administered orally as an inhibitor of platelet aggregation. Due to the high price of the original brand of Clopidogrel (Plavix), an Iranian brand...

  • Myocardial revascularization in 1997: Angioplasty versus... Faxon, David P. // American Family Physician;10/1/1997, Vol. 56 Issue 5, p1409 

    Focuses on angioplasty and coronary artery bypass graft surgery for the treatment of patients with coronary artery disease and severe ischemia. Information on the first coronary artery bypass graft surgery; Information on the Randomized Intervention Treatment of Angina (RITA) Trial, the first...

  • Effects of preoperative magnesium therapy on arrhythmias and myocardial ischemia during off-pump coronary surgery. Beşoğul, Yavuz; Gemalmaz, Hüseyin; Aslan, Recep // Journal of Conservative Dentistry;Jan/Feb2009, Vol. 12 Issue 1, p137 

    BACKGROUND: Heart manipulation during off-pump coronary artery bypass surgery may cause hemodynamic instability, and temporary coronary arterial occlusion may lead to myocardial ischemia. To reduce this, perioperative β-blocking agents or calcium antagonists can be administrated. The effects...

  • Effect of Revascularization of Chronic Total Occlusion on Tandem Stenoses in a "Donor" Artery. Sachdeva, Rajesh // Texas Heart Institute Journal;Sep2014, Vol. 41 Issue 5, p547 

    The presence, severity, and extent of ischemia predict the outcome of coronary artery disease. Indeed the extent of myocardial ischemia and viability determines the value of revascularization in coronary stenosis after acute myocardial infarction. In multivessel coronary artery disease,...

  • Depression and Coronary Artery Disease: Is There a Platelet Link? Ziegelstein, Roy C.; Parakh, Kapil; Sakhuja, Ankit; Bhat, Utsav // Mayo Clinic Proceedings;Nov2007, Vol. 82 Issue 11, p1366 

    The article focuses on the potential link between mental depression and coronary artery disease. According to the author, researchers have suggested several pathways whereby depression might affect outcomes in patients with coronary artery disease. It is concluded that adequately powered studies...

  • Intercoronary communication between the circumflex and right coronary arteries: distinct from coronary collaterals. Atak, R.; Guray, U.; Akin, Y. // Heart;Jul2002, Vol. 88 Issue 1, p29 

    Presents a case of intercoronary artery continuity with atypical chest pain. Findings of the coronary angiography; Types of intercoronary artery continuity; Selective injection of the right coronary artery.

  • Obstruction of Coronary Artery--1912. Herrick, James B. // Annals of Internal Medicine;Dec76, Vol. 85 Issue 6, p803 

    Presents an excerpt from the article 'Clinical Features of Sudden Obstruction of the Coronary Arteries,' published in the 1912 issue of the 'Journal of American Medical Association.'

  • Newly developed lesions in right coronary artery during PCI. Güler, Ahmet; Güler, Yeliz; Kırma, Cevat // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Aug2014, Vol. 14 Issue 5, p484 

    A quiz concerning a case study of a 57-year-old male who was diagnosed with newly developed lesions in right coronary artery during percutaneous coronary intervention (PCI).