TITLE

Computational biology: Protein predictions

AUTHOR(S)
Dodson, Eleanor J.
PUB. DATE
November 2007
SOURCE
Nature;11/8/2007, Vol. 450 Issue 7167, p176
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the study that assesses the three-dimensional structure of proteins from its amino-acid sequence through X-ray diffraction and nuclear magnetic resonance (NMR). The peptide sequence is mapped against the existing information, and energy profile of each atom is incorporated into the low-energy models. Findings reveal that the shape of the protein matches with the lowest-energy conformation of the molecule that reflects the combined properties of amino acids. It also indicates an achievement of amino acid hydrogen-bonding as well as side-chain interactions in certain structures.
ACCESSION #
27420812

 

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