TITLE

Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?

AUTHOR(S)
Han, S. Duke; Drake, Angela I.; Cessante, Lynne M.; Jak, Amy J.; Houston, Wes S.; Delis, Dean C.; Filoteo, J. Vincent; Bondi, Mark W.
PUB. DATE
October 2007
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Oct2007, Vol. 78 Issue 10, p1103
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Although research has implicated the apolipoprotein E (APOE) epsilon-4 genotype as having a negative effect on neuropsychological outcomes following traumatic brain injury (TBI), the potentially negative role of the &3x20AC;4 allele on TBI outcomes has recently been challenged. In light of this debate, the present study served to examine the role of APOE genotype on neuropsychological outcomes approximately 1 month following mild to moderate TBI in a military population. Because of the well documented role of the APOE-ϵ4 allele in increasing the risk of Alzheimer's disease, we predicted that persons with the APOE--ϵ4 genotype would display relatively greater deficits in cognition than their non-c4 counterparts. Methods: 78 participants were consecutively recruited following a mild to moderate TBI and were divided into two groups based on the presence or absence of an APOE &3x20AC;4 allele. Groups were comparable on demographic characteristics and psychosocial outcomes. Participants were administered a comprehensive neuropsychological battery. Results: Analyses revealed comparable performances on most neuropsychological measures and better performances by &3x20AC;4 carriers on select measures of attention, executive functioning and episodic memory encoding. Furthermore, differences remained after accounting for the effects of TBI severity. Conclusions: Evidence from these analyses supports current literature refuting the notion of relatively poorer neuropsychological functioning associated with the APOE--ϵ4 genotype among young adult participants shortly following mild or moderate brain injury. Neuropsychological performance differences by APOE genotype following TBI are discussed in terms of the importance of considering severity of injury, timing of postinjury assessment and possible neurocognitive compensatory mechanisms.
ACCESSION #
27403053

 

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