Fat or bone? A non-canonical decision

Günther, Thomas; Schüle, Roland
November 2007
Nature Cell Biology;Nov2007, Vol. 9 Issue 11, p1229
Academic Journal
The transcription factor PPAR-γ determines whether mesenchymal stem cells differentiate into adipocytes or osteoblasts. The finding that non-canonical Wnt signalling represses PPAR-γ through assembly of a nuclear corepressor complex containing the histone methyltransferase SETDB1 provides the first insight into how extracellular signals can regulate chromatin modification.


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