TITLE

Role of ranibizumab in management of macular degeneration

AUTHOR(S)
Singh, Rishi P.; Kaiser, Peter K.
PUB. DATE
November 2007
SOURCE
Indian Journal of Ophthalmology;Nov2007, Vol. 55 Issue 6, p421
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Age-related macular degeneration (AMD) is one of the most common causes of severe vision loss in the western world. Both animal and human studies have established that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of this process. Ranibizumab (Lucentis(TM) Genentech, South San Francisco, CA) is a monoclonal antibody fragment (Fab) directed toward all isoforms of VEGF-A that was specifically designed to target wet AMD. The human antibody fragment is produced by an E. coli expression system and has a molecular weight of 48kD allowing for excellent retinal penetration. The most common ocular complaints of patients receiving ranibizumab injections in randomized clinical trials were transient conjunctival hemorrhage, vitreous floaters, intraocular inflammation, increased intraocular pressure and eye pain. The rates of serious adverse events such as retinal detachment, cataract and endophthalmitis were similar to those that have been reported with other intravitreal injections and patients should always be treated under strict aseptic conditions to reduce this risk. There were no significant non-ocular events found during any study so far and the risk of thromboembolic events was less than 4% and not different than sham. The MARINA, ANCHOR and PIER studies validated the safety and efficacy of ranibizumab amongst a large population with different choroidal neovascular membrane lesion types against sham or standard of care treatment. These studies recommended monthly intravitreal ranibizumab for patients. However, the PIER study reported that an alternative dosing of every three months is acceptable but less effective than monthly injections.
ACCESSION #
27260097

 

Related Articles

  • Data: Ranibizumab achieves higher BCVA gains for BRVO in COMRADE-B. Dalton, Michelle; Taylor, Simon R. J. // Ophthalmology Times;Mar2015, Vol. 40 Issue 4, p30 

    The article discusses the COMRADE-B randomized, controlled clinical trial, which compares the efficacy of ranibizumab or Lucentis, an anti-vascular endothelial growth factor (VEGF) from biotechnology firm Genentech, with Ozurdex, a dexamethasone intravitreal implant from pharmaceutical firm...

  • Anti-VEGFs equivalent in IVAN2, GEFAL trials. Charters, Lynda; Kodjikian, Laurent // Ophthalmology Times;6/15/2013, Vol. 38 Issue 12, p8 

    The article discusses the findings of two randomized clinical trials which revealed the similar efficacy of bevacizumab and ranibizumab, two anti-vascular endothelial growth factor (VEGF) drugs for age-related macular degeneration (AMD) treatment, for improving vision. It describes the procedure...

  • Sonepcizumab, anti-VEGF may yield long-term visual acuity. Charters, Lynda // Ophthalmology Times;11/15/2016, Vol. 41 Issue 19, p26 

    The article reports on the Nexus Study on the monoclonal antibody sonepcizumab and its effect of improving visual acuity and potential for long-term stabilization for patients diagnosed with age-related macular degeneration (AMD). Topics include the efficacy of sonepcizumab monotherapy and in...

  • Frequency of anti-VEGF treatment trends toward extended intervals.  // Ocular Surgery News;2/25/2014, Vol. 32 Issue 4, p1 

    The article reports that anatomic changes detected on spectral-domain optical coherence tomography will be considered in deciding to retreat patients with age-related macular degeneration with anti-vascular endothelial growth factor (VEGF) injections according to ophthalmologist Dr. Elias Reichel.

  • Benefits of anti-VEGF therapy for DME durable to 3 years. Krader, Cheryl Guttman; Feiner, Leonard // Ophthalmology Times;8/15/2013, Vol. 38 Issue 16, p18 

    The article presents the use of ranibizumab for diabetic macular edema (DME). It discusses the medication which is a type of anti-vascular endothelial growth factor (VEGF) and use for treatment of blood vessel growth and leakage in the eye that may result to vision loss. It describes the...

  • Intravitreal Combination of Dexamethasone Sodium Phosphate and Bevacizumab in The Treatment of Exudative AMD. Vakalis, N.; Echiadis, G.; Pervena, A.; Deligiannis, I.; Kavalarakis, E.; Giannikakis, S.; Papaefthymiou, I. // Scientific Reports;2/27/2015, p8627 

    The purpose of this study is to investigate the efficacy and safety of intravitreal dexamethasone sodium phosphate (DSP) combined with bevacizumab for the treatment of neovascular age-related macular degeneration (AMD). In this non comparative case study, 30 eyes of 27 patients with CNV due to...

  • Clinical Diagnosis. Managing retinal vaso-occlusive diseases. Groves, Nancy; Suñer, Ivan J. // Ophthalmology Times;10/15/2014, Vol. 39 Issue 19, p36 

    The article reviews a study that determined the effectivity of ranibizumab injection through an ultra-widefield fluorescein angiography-guided injection for branch retinal vein occlusion (BRVO) in patients with macular edema. Topics covered include ranibizumab blocking vascular endothelial...

  • Early anti-VEGF response predicts longer-term results. Gebhart, Fred; Whitcup, Scott M. // Ophthalmology Times;7/1/2016, Vol. 41 Issue 11, p20 

    The article discusses a study which revealed that early response to agents which block vascular endothelial growth factor (VEGF) can predict longer-term improvement in visual acuity in patients with diabetic macular edema (DME). Topics covered include the clinical implication of the study and...

  • Age-related macular degeneration. Ong, B. B.; Ah-Fat, F. G. // British Journal of Hospital Medicine (17508460);Feb2016, Vol. 77 Issue 2, pC18 

    The article discusses clinical information on age-related macular degeneration (AMD). Topics explored include the percentage of visual impairment cases in Great Britain which may be attributed to AMD, pathophysiological factors which characterize geographic atrophy and exudative AMD, and...

  • New anti-VEGF shows good results in poor responders to previous anti-VEGF therapy.  // Ocular Surgery News;7/25/2013, Vol. 31 Issue 14, p14 

    The article focuses on the therapeutic use and efficacy of aflibercept, an anti-vascular endothelial growth factor (VEGF) drug, compared to other anti-VEGF therapy, discussed by ophthalmologist Stephan Michels during the 2013 European Society of Ophthalmology meeting in Copenhagen, Denmark.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics