No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome

Taylor, Brent; Andrews, Nick; Stowe, Julia; Hamidi-Manesh, Laila; Miller, Elizabeth
October 2007
Archives of Disease in Childhood;Oct2007, Vol. 92 Issue 10, p887
Academic Journal
Objectives: To investigate whether meningococcal C conjugate vaccine (MCCV) caused relapse in children with steroid-responsive nephrotic syndrome. Design: A population-based study was conducted using an active surveillance system, developed to assess adverse events following vaccination, which linked hospital record information on relapses of nephrotic syndrome to community child health population MCCV data. An ecological study looking at hospital admissions for nephrotic syndrome in different age cohorts of children before and after the MCCV introductory campaign was also carried out. Settings: South East England, and England and Wales. Patients: 52 children having 162 relapses of nephrotic syndrome. Also, all hospital admissions of children aged 2-18 years with steroid-responsive nephrotic syndrome in England and Wales between 1995 and 2003, relating admissions to when MCCV was introduced in specific age cohorts. Main outcome measures and analysis method: Self-controlled case series analysis looking for increased risk of relapse following MCCV and changes in admission rates for nephrotic syndrome (incidence ratio) following the introduction of MCCV to different age cohorts of children. Results: There was no increased risk of relapse following MCCV in the self-control case series, where a relative incidence of 0.95 (95% confidence interval (CI) 0.61–1.47) was found in the 6-month post-vaccination period, or in the ecological study, which gave an incidence rate ratio of 1 .05 (95% CI 0.95 to 1.15) for the quarter when MCCV was introduced and the following two quarters. Conclusions: We found no association between MCCV and nephrotic syndrome, which is therefore not a contraindication to meningococcal vaccination.


Related Articles

  • Recommendation from the Advisory Committee on Immunization Practices (ACIP) for Use of Quadrivalent Meningococcal Conjugate Vaccine (MCV4) in Children Aged 2-10 Years at Increased Risk for Invasive Meningococcal Disease.  // MMWR: Morbidity & Mortality Weekly Report;12/7/2007, Vol. 56 Issue 58, p1265 

    The article provides updated recommendations for Quadrivalent Meningococcal Conjugate Vaccine (MCV4) among children at increased risk the disease. In a controlled study, serum bactericidal antibody geometric mean titers against serogroups were higher after vaccination with MCV4. Children who are...

  • A single-center study of C1q nephropathy in children. Roberti, Isabel; Baqi, Noosha; Vyas, Shefali; Kim, Dae // Pediatric Nephrology;Jan2009, Vol. 24 Issue 1, p77 

    C1q nephropathy (C1qN) is a rare idiopathic glomerulopathy typically seen in adolescents and young adults. All kidney biopsies done from 2002 to 2007 were analyzed (264). Thirteen cases of C1qN from 212 (6.6%) native biopsies and one case out of 52 (1.9%) transplant biopsies were reviewed...

  • Management patterns of childhood-onset nephrotic syndrome. MacHardy, Nathaniel; Miles, Paul V.; Massengill, Susan; Smoyer, William; Mahan, John; Greenbaum, Larry; Massie, Sara; Yao, Lynne; Nagaraj, Shashi; Jen-Jar Lin; Wigfall, Delbert; Trachtman, Howard; Yichun Hu; Gipson, Debbie // Pediatric Nephrology;Nov2009, Vol. 24 Issue 11, p2193 

    As an initial effort to identify opportunities to improve the management of children with nephrotic syndrome, the goal of this study was to assess the present-day management of children with primary nephrotic syndrome. A web-based survey was designed to assess the current management styles of...

  • Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome? Gulati, Sanjeev; Tripathi, Piyush; Patil, Siddramappa J.; Sharma, Raj Kumar; Agarwal, Suraksha // Pediatric Nephrology;Apr2007, Vol. 22 Issue 4, p528 

    This study was conducted to test the hypothesis that analysis of HLA class II type alleles will give important information on the prognosis of NS in children. We prospectively studied 100 consecutive children with idiopathic nephrotic syndrome and 202 controls belonging to the same geoethnic...

  • Pattern of double glomerulopathy in children. Hae Cheong; Hee Yeon Cho; Kyung Chul Moon; Il Soo Ha; Yong Choi // Pediatric Nephrology;Apr2007, Vol. 22 Issue 4, p521 

    Occasional case reports have been issued on children with double glomerulopathy, involving either the coexistence of two different glomerulopathies or superimposition of a second glomerulopathy onto a first. A retrospective clinicopathological review of 294 children who had received renal...

  • Registry-Driven, Community-Based Immunization Outreach. Wilcox, Sarah A.; Koepke, Christopher P.; Levenson, Robert; Thalheimer, Judith C. // American Journal of Public Health;Sep2001, Vol. 91 Issue 9, p1507 

    Conclusions. Registry-driven outreach can effectively identify high-risk children and bring them to care. (Am J Public Health. 2001;91:1507-1511)

  • High Incidence of FSGS in Children.  // Kidney;Nov/Dec99, Vol. 8 Issue 6, p240 

    Focuses on the possible changes in the etiology of childhood nephrosis in a racially mixed urban population. Presence of minimal change nephrotic syndrome in 35 percent of all biopsies and focal segmental glomerulosclerosis (FSGS) in 31 percent; Finding that FSGS is the most common cause of...

  • Red blood cell aggregation in nephrotic syndrome. Ozanne, Patrick; Francis, Robert B.; Meiselman, Herbert J. // Kidney International;Mar1983, Vol. 23 Issue 3, p519 

    Red blood cell (RBC) aggregation induced by fibrinogen is a major determinant of the non-Newtonian flow behavior of human blood and has been suggested as a possible contributing factor for thrombogenesis. Given the elevated fibrinogen levels and the high incidence of thrombotic accidents in...

  • Renal Diseases.  // Kidney International;Dec1979, Vol. 16 Issue 6, p861 

    Discusses abstracts of studies related to renal diseases published as of December 1979. Comparison of age related histology in minimal change nephrotic syndrome; Study about the behavior of anionic charges of podocytes in nephrotic subjects.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics