Familial hemiplegic migraine with prolonged hemiplegia

October 2007
Archives of Disease in Childhood;Oct2007, Vol. 92 Issue 10, p886
Academic Journal
The article offers information about the familial hemiplegic migraine (FHM), an autosomal dominant classical migraine that is characterized by attack starting with unilateral paresthesia and weakness lasting for around 30 to 60 minutes. FHM is composed of three genetic subgroups including FHM1, a migraine due to mutations in the gene CACNAIA encoding a neuronal calcium channel subunit, FHM2, a migraine due to mutations in the gene ATPase isozyme 2, and FHM3, a migraine due to mutations in the gene SCN1A. Moreover, ataxia and interictal nystagmus are observed in FHM1 while seizures are found in FHM2 and FHM3.


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