TITLE

Multinucleate Giant Cells Release Functionally Unopposed Matrix Metalloproteinase-9 In Vitro and In Vivo

AUTHOR(S)
Xing Wu Zhu; Price, Nicholas M.; Gilman, Robert H.; Recarvarren, Sixto; Friedland, Jon S.
PUB. DATE
October 2007
SOURCE
Journal of Infectious Diseases;10/1/2007, Vol. 196 Issue 7, p1076
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Multinucleated giant cells (MGCs) are characteristic of granulomatous inflammation. Matrix metalloproteinase (MMP)—9, the major monocyte-derived matrix metalloproteinase, is key in inflammatory tissue damage. At 72 h, MGCs secrete 153 ± 2.5 ng/mL MMP-9, compared with 115 ± 3.8 ng/mL during macrophage differentiation (P<.05). In contrast, the level of MGC secretion-specific tissue inhibitor, tissue inhibitor of metalloproteinase (TIMP)–1, is lower (P< 05). Mature MGCs secrete constitutively greater concentrations of MMP-9 than do monocytes or macrophages (P<.05). MGCs in tuberculous lymph-node biopsy samples express high MMP-9 levels adjacent to areas of necrosis, whereas TIMP- 1 is not detected. Thus, MGCs are potentially important sources of MMP-9 secretion and may contribute to inflammatory tissue damage in human tuberculosis.
ACCESSION #
27150434

 

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