Multinucleate Giant Cells Release Functionally Unopposed Matrix Metalloproteinase-9 In Vitro and In Vivo

Xing Wu Zhu; Price, Nicholas M.; Gilman, Robert H.; Recarvarren, Sixto; Friedland, Jon S.
October 2007
Journal of Infectious Diseases;10/1/2007, Vol. 196 Issue 7, p1076
Academic Journal
Multinucleated giant cells (MGCs) are characteristic of granulomatous inflammation. Matrix metalloproteinase (MMP)—9, the major monocyte-derived matrix metalloproteinase, is key in inflammatory tissue damage. At 72 h, MGCs secrete 153 ± 2.5 ng/mL MMP-9, compared with 115 ± 3.8 ng/mL during macrophage differentiation (P<.05). In contrast, the level of MGC secretion-specific tissue inhibitor, tissue inhibitor of metalloproteinase (TIMP)–1, is lower (P< 05). Mature MGCs secrete constitutively greater concentrations of MMP-9 than do monocytes or macrophages (P<.05). MGCs in tuberculous lymph-node biopsy samples express high MMP-9 levels adjacent to areas of necrosis, whereas TIMP- 1 is not detected. Thus, MGCs are potentially important sources of MMP-9 secretion and may contribute to inflammatory tissue damage in human tuberculosis.


Related Articles

  • Response of Lymphocyte Subsets in Patients Under Treatment for Tuberculosis. Collazos, J.; Martínez, E.; Mayo, J.; Riñón, M. // European Journal of Clinical Microbiology & Infectious Diseases;Aug2000, Vol. 19 Issue 8, p623 

    Thirty-six immunocompetent patients with tuberculosis underwent six sequential measurements of blood lymphocyte subsets after the onset of therapy. Two different responses were observed, depending on each patient's initial lymphocyte count. Patients with initial lymphocytopaenia showed a marked...

  • Znacaj ultrazvucnog pregleda terminalnog ileuma kod srednje te�kog oblika Kronove bolesti. Lukic-Kostic, Leposava; Jovic, Jasna; Sekulovic, Slobodan // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Sep2006, Vol. 63 Issue 9, p787 

    Background/Aim. Crohn's disease (CD) is a chronic granulomatous inflammatory disease of unknown etiology, involving any part of the gastrointestinal tract, and frequently followed by extraintestinal manifestations. The use of ultrasonography plays a significant role in diagnosing this disease,...

  • Natural Variation in Immune Responses to Neonatal Mycobacterium bovis Bacillus Calmette-Guerin (BCG) Vaccination in a Cohort of Gambian Infants. Finan, Chris; Ota, Martin O. C.; Marchant, Arnaud; Newport, Melanie J. // PLoS ONE;2008, Vol. 3 Issue 10, p1 

    Background: There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective. However, BCG could remain integral to TB control programmes because neonatal BCG protects against disseminated forms of childhood TB and many new...

  • Combined DNA Vaccines Formulated in DDA Enhance Protective Immunity against Tuberculosis. Cai, H.; Tian, X.; Hu, X. D.; Zhuang, Y. H.; Zhu, Y. X. // DNA & Cell Biology;Jul2004, Vol. 23 Issue 7, p450 

    This study evaluated the adjuvant Dimethyldioctyldecyl Ammonium Bromide (DDA) effect on the protective immunity induced by a combination of plasmids containing genes encoding antigens Ag85B, MPT-83, and ESAT-6 from Mycobacterium tuberculosis. The combined DNA vaccines in DDA resulted in...

  • MORPHOLOGICAL STUDY OF PATHOLOGICAL LESIONS SEEN IN PLEURAL BIOPSIES. Memon, Jawaid Hussain; Sadiq, Saleem // Pakistan Journal of Medical Sciences;Jul2010, Vol. 26 Issue 3, p673 

    Objective: To determine the frequency and types of different pathological lesions seen in pleural biopsies in our patients. Methodology: This is a prospective study carried out in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. A total...

  • Complications of Tumor Necrosis Factor—α Blockade in Chronic Granulomatous Disease—Related Colitis. Uzel, Gulbu; Orange, Jordan S.; Poliak, Nina; Marciano, Beatriz E.; Heller, Theo; Holland, Steven M. // Clinical Infectious Diseases;12/15/2010, Vol. 51 Issue 12, p1429 

    Background. Chronic granulomatous disease (CGD) is a genetic disorder of the phagocyte NADPH oxidase, which predisposes patients to infections and inflammatory complications, including severe colitis. Management of CGD colitis is a challenge because standard immunosuppressive therapy increases...

  • Nonneoplastic Lung Disease--More Than Just Usual Interstitial Pneumonia. Beasley, Mary Beth // Archives of Pathology & Laboratory Medicine;May2010, Vol. 134 Issue 5, p665 

    The article discusses various reports published within the issue including one by Sanjay Mukhopadhyay and Tony Gal on pulmonary granulomatous disorders, one by Donald Guinee on differential diagnosis and clinical significance of nonneoplastic lymphoid disorders, and one by Tim Allen on the...

  • Identification of Mycobacterial Genes That Alter Growth and Pathology in Macrophages and in Mice. Chang, Jennifer C.; Harik, Nada S.; Liao, Reiling P.; Sherman, David R. // Journal of Infectious Diseases;9/1/2007, Vol. 196 Issue 5, p788 

    Mycobacterium tuberculosis lives intracellularly, and many facets of its interactions with host cells are not well understood. We screened an M. tuberculosis transposon library for mutants exhibiting reduced ability to kill eukaryotic cells. Four of the mutants identified had insertions in 3...

  • CROHN'S DISEASE (REGIONAL ENTERITIS). Terezhalmy, Geza T.; Riley, Catherine K. // Quintessence International;Nov1999, Vol. 30 Issue 11, p794 

    The article focuses on Crohn's Disease (Regional Enteritis). The definition is the chronic granulomatous inflammation of unknown etiology, extending through all layers of the bowel wall. The ileum is most often affected, but any portion of the gastrointestinal tract from the mouth to the anus...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics