TITLE

SERRATED PATHWAY COLORECTAL CANCER IN THE POPULATION: GENETIC CONSIDERATION

AUTHOR(S)
Young, Joanne; Jenkins, Mark; Parry, Susan; Young, Bruce; Nancarrow, Derek; English, Dallas; Giles, Graham; Jass, Jeremy
PUB. DATE
October 2007
SOURCE
Gut;Oct2007, Vol. 56 Issue 10, p1453
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article explores the evidence of the development of advanced serrated polyps. It has been found that it is a genetic trait with implications for colorectal cancer and prevention in the wider population. One of the most important seeds for this change has been the recognition of a serrated polyp pathway-type colorectal tumorigenesis associated with somatic BRAF mutation and widespread gene promoter hypermethylation as an alternative to the adenoma-carcinoma sequence.
ACCESSION #
27148482

 

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