New serological markers in inflammatory bowel disease are associated with complicated disease behaviour

Ferrante, Marc; Henckaerts, Liesbet; Joossens, Marie; Pierik, Marie; Joossens, Sofie; Dotan, Nir; Norman, Gary L.; Altstock, Rom T.; van Steen, Kristel; Rutgeerts, Paul; van Assche, Gert; Vermeire, Séverine
October 2007
Gut;Oct2007, Vol. 56 Issue 10, p1394
Academic Journal
Background and aims: Several antibodies have been associated with Crohn's disease and are associated with distinct clinical phenotypes. The aim of this study was to determine whether a panel of new antibodies against bacterial peptides and glycans could help in differentiating inflammatory bowel disease (IBD), and whether they were associated with particular clinical manifestations. Methods: Antibodies against a mannan epitope of Saccharomyces cerevisiae (gASCA), laminaribioside (ALCA), chitobioside (ACCA), mannobioside (AMCA), outer membrane porins (Omp) and the atypical perinuclear antineutrophilic cytoplasmic antibody (pANCA) were tested in serum samples of 1225 IBD patients, 200 healthy controls and 113 patients with non-IBD gastrointestinal inflammation. Antibody responses were correlated with the type of disease and clinical characteristics. Results: 76% of Crohn's disease patients had at least one of the tested antibodies. For differentiation between Crohn's disease and ulcerative colitis, the combination of gASCA and pANCA was most accurate. For differentiation between IBD, healthy controls and non-IBD gastrointestinal inflammation, the combination of gASCA, pANCA and ALCA had the best accuracy. Increasing amounts and levels of antibody responses against gASCA, ALCA, ACCA, AMCA and Omp were associated with more complicated disease behaviour (44.7% versus 53.6% versus 71.1% versus 82.0%, p < 0.001), and a higher frequency of Crohn's disease-related abdominal surgery (38.5% versus 48.8% versus 60.7% versus 75.4%, p < 0.001). Conclusions: Using this new panel of serological markers, the number and magnitude of immune responses to different microbial antigens were shown to be associated with the severity of the disease. With regard to the predictive role of serological markers, further prospective longitudinal studies are necessary.


Related Articles

  • Platelets in inflammatory bowel disease. Matsumoto, Takayuki // Journal of Gastroenterology;Jan2006, Vol. 41 Issue 1, p91 

    The article discusses the increased accumulation response of platelets in patients with inflammatory bowel disease (IBD). The regulation of the platelet activation for IBD has the potential for a successful treatment of the disease. A study has found out that platelets play an important role in...

  • The forgotten role of lymphangitis in Crohn's disease. Kruiningen, H J Van; Colombel, Jean-Frédéric // Gut;Jan2008, Vol. 57 Issue 1, p1 

    Research into Crohn's disease has recently been focused on the genetics of the patient, the gastrointestinal flora, the gut epithelium and mucosal immune responses. For over 60 years pathologists have reported that the fundamental alteration in Crohn's disease occurs in regional lymphatics of...

  • Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Summers, Robert W.; Elliott, David E.; Qadir, Khurram; Urban Jr., Joseph F.; Thompson, Robin; Weinstock, Joel V. // American Journal of Gastroenterology;Sep2003, Vol. 98 Issue 9, p2034 

    : ObjectivesInflammatory bowel disease (IBD), especially Crohn''s disease (CD), probably results from failure to downregulate a chronic Th1 intestinal inflammatory process. Induction of a Th2 immune response by intestinal helminths diminishes Th1 responsiveness. This study evaluates the safety...

  • Anti-Tumor Necrosis Factor-Alpha (TNF-α) Treatment Strategies in Crohn's Disease. Reimund, Jean-Marie; Ratajczyk, Julia; Sola, Brigitte; Justum, Anne-Marie; Muller, Christian D. // Recent Patents on Inflammation & Allergy Drug Discovery;Feb2007, Vol. 1 Issue 1, p21 

    Crohn's disease is a complex multifactorial disorder characterized by the alternation of a cytokine-driven Tlymphocyte-depending inflammation of the intestinal mucosa, and "off" periods, where patients are completely asymptomatic. Although all the causative factors have not been clearly...

  • Crohn's Disease and Intestinal Bacteria. Klotter, Jule // Townsend Letter;Jun2013, Issue 359, p20 

    The article reports on the connection between potentially disease-causing bacteria called pathobionts and Crohn's disease (CD). According to Dutch researcher Hermie J. M. Harmsen and colleagues, people with CD experience chronic gut inflammation because of a heightened immune response to...

  • Viagra for the gut.  // New Scientist;3/4/2006, Vol. 189 Issue 2541, p19 

    This article reports that according to a new study, Viagra can help treat Crohn's disease. A team from University College, London, England, carried out biopsies on six Crohn's disease patients and nine healthy volunteers. The operation triggered an acute immune response in the healthy people,...

  • Evolving paradigms in the pathogenesis of IBD. Mayer, Lloyd // Journal of Gastroenterology;Jan2010, Vol. 45 Issue 1, p9 

    The pathogenesis of all immune-mediated inflammatory diseases has been carefully studied over the past several decades, but it is only recently that we have come to appreciate common pathways and genes. This is especially true for the inflammatory bowel diseases (IBD) Crohn’s disease and...

  • Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients. Braat, Henri; Stokkers, Pieter; Hommes, Tijmen; Cohn, Danny; Vogels, Esther; Pronk, Inge; Spek, Arnold; Kampen, Antoine; Deventer, Sander; Peppelenbosch, Maikel; Hommes, Daan // Journal of Molecular Medicine;Aug2005, Vol. 83 Issue 8, p601 

    The concept that mutations in germ-line encoded pattern recognition receptors with immune activating functions are associated with an increased incidence in Crohn’s disease (CD) is gaining acceptance. Whether these mutations have similar or distinct effects on cellular physiology remains...

  • Markery serologiczne w diagnostyce nieswoistych zapaleÅ„ jelit - nowe zastosowania w praktyce. Mokrowiecka, Anna; Kumor, Anna; Małecka-Panas, Ewa // Gastroenterologia Polska / Gastroenterology;2007, Vol. 14 Issue 4, p289 

    The key role of immune system in IBD pathogenesis leads to the hypothesis that serological markers may be of value in ulcerative colitis/Crohn's disease (UC/CD) diagnosis and differentiation. Many types of serological markers have been analyzed due to their usefulness in disease activity...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics