The IL23 axis plays a key role in the pathogenesis of IBD

McGovern, Dermot; Powrie, Fiona
October 2007
Gut;Oct2007, Vol. 56 Issue 10, p1333
Academic Journal
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.


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