TITLE

The IL23 axis plays a key role in the pathogenesis of IBD

AUTHOR(S)
McGovern, Dermot; Powrie, Fiona
PUB. DATE
October 2007
SOURCE
Gut;Oct2007, Vol. 56 Issue 10, p1333
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
ACCESSION #
27148451

 

Related Articles

  • Role of alkaline phosphatase in colitis in man and rats. A Tuin // Gut;Mar2009, Vol. 58 Issue 3, p379 

    BACKGROUND AND AIMS: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands,...

  • Molecular prediction of disease risk and severity in a large Dutch Crohn’s disease cohort. R K Weersma // Gut;Mar2009, Vol. 58 Issue 3, p388 

    BACKGROUND: Crohn’s disease and ulcerative colitis have a complex genetic background. We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD). METHODS: We studied 2804...

  • Role of Procalcitonin in Infectious Gastroenteritis and Inflammatory Bowel Disease. Kelvin Thia; Edwin Chan; Khoon-Lin Ling; Wai-Yoong Ng; Edward Jacob; Choon-Jin Ooi // Digestive Diseases & Sciences;Nov2008, Vol. 53 Issue 11, p2960 

    Abstract   Background and Aim We have evaluated procalcitonin (PCT) as a diagnostic marker for bacterial gastroenteritis (GE) and as a disease activity marker in inflammatory bowel disease (IBD) patients. Methods This was a prospective single-center study performed over a 1-year...

  • Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs. Yoon Suk Jung; Jae Hee Cheon; Jae Jun Park; Chang Mo Moon; Eun Soo Kim; Jin Ha Lee; Seung Won Kim; Jae Hak Kim; Sung Pil Hong; Tae Il Kim; Won Ho Kim // Journal of Human Genetics;Feb2010, Vol. 55 Issue 2, p121 

    There is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We investigated whether TPMT/ITPA genotypes predicted long-term clinical response in Korean patients with...

  • Coping With Crohn's Disease. Waters, Jen // World & I;Jun/Jul2006, Vol. 21 Issue 6, p20 

    The article considers the cause, diagnosis and treatment of Crohn's disease. Crohn's disease is a type of inflammatory bowel disease, a family of diseases that cause irritation in the intestines. Because the occurrence of Crohn's disease parallels peptic ulcer disease, it would suggest that the...

  • Inflammatory Bowel Disorders.  // Current Medical Literature: Gastroenterology;2011, Vol. 30 Issue 1, p21 

    The article discusses various research that explored the different aspects of inflammatory bowel disorders. One of the studies dealt with the changes in surgical resection rates and medical treatments for Crohn's disease. Another research focused on the association of pre-operative management...

  • New therapeutic approach in inflammatory bowel disease. PAPA, A.; MOCCI, G.; SCALDAFERRI, F.; BONIZZI, M.; FELICE, C.; ANDRISANI, G.; GASBARRINI, A. // European Review for Medical & Pharmacological Sciences;Jan2009 Supplement, Vol. 13 Issue S-1, p33 

    In the last decade, biologic agents, in particular infliximab and adalimumab, have deeply changed the therapeutic armamentarium of inflammatory bowel disease (IBD). However, these drugs have a number of contraindications and side-effects that physicians should know so to avoid and eventually...

  • "It doesn't do any harm, but patients feel better": a qualitative exploratory study on gastroenterologists' perspectives on the role of antidepressants in inflammatory bowel disease. Mikocka-Walus, Antonina A; Turnbull, Deborah A; Moulding, Nicole T; Wilson, Ian G; Andrews, Jane M; Holtmann, Gerald J // BMC Gastroenterology;2007, Vol. 7, p38 

    Background: Interest in psychological factors in patients with inflammatory bowel disease (IBD) has increased in recent years. It has even been proposed that treating psychological co-morbidities with antidepressants may control disease activity and improve quality of life. Despite this, there...

  • Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis. Wang Fan; Wang Maoqing; Chen Wangyang; Hu Fulan; Li Dandan; Ren Jiaojiao; Dong Xinshu; Cui Binbin; Zhao Yashuang // European Journal of Human Genetics;Apr2011, Vol. 19 Issue 4, p432 

    Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are common health problems worldwide. Tumor necrosis factor (TNF) is a type of cytokine that induces inflammation and inhibits tumorigenesis. Several studies have assessed the relationship between the polymorphism of TNF-α-308 G>A...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics