Early Accuracy in New Drug Safety Analysis

Yanowitz, Frank G.
October 2007
Applied Clinical Trials;Oct2007 Supplement, p12
Academic Journal
The article discusses the methodologies for evaluating the risk of noncardiovascular drugs for Torsade de pointes and other life-threatening arrhythmias. In this paper, limitations in guidelines are considered and recommendations for further study are reviewed. Torsade de Pointes is a ventricular tachycardia that has its origin in patients with hereditary or acquired long QT syndrome. Arrhythmia degenerates into ventricular fibrillation leading to syncope.


Related Articles

  • "Les Torsades de Pointes": An Unusual Ventricular Arrhythmia. Smith, Warren M.; Gallagher, John J. // Annals of Internal Medicine;Oct80, Vol. 93 Issue 4, p578 

    Focuses on the unusual ventricular arrhythmia 'les torsades de pointes.' Problem with characterizing the arrhythmia; Description and diagnostic features; Relation of the arrhythmia with ventricular tachycardia and fibrillation; Causes of torsades de pointes; Treatment and prevention.

  • Transvenous atrial pacing in the treatment of refractory ventricular irritability. Kastor, John A.; DeSanctis, Roman W.; Harthorne, J. Warren; Schwartz, Gabriel H.; Kastor, J A; DeSanctis, R W; Harthorne, J W; Schwartz, G H // Annals of Internal Medicine;May67, Vol. 66 Issue 5, p939 

    Focuses on the use of transvenous atrial pacing on three occasions in two patients with refractory ventricular tachycardia and ventricular fibrillation occurring in the absence of atrioventricular (AV) block. Potential reasons for the development of arrhythmias; Recommended treatment for...

  • Cardiac arrhythmia classification using autoregressive modeling. Dingfei Ge; Srinivasan, Narayanan; Krishnan, Shankar M. // BioMedical Engineering OnLine;2002, Vol. 1, p5 

    Background: Computer-assisted arrhythmia recognition is critical for the management of cardiac disorders. Various techniques have been utilized to classify arrhythmias. Generally, these techniques classify two or three arrhythmias or have significantly large processing times. A simpler...

  • Molecular Predictors of Drug-induced Prolongation of the QT Interval. Dilaveris, Polychronis E.; Stefanadis, Christodoulos I. // Current Medicinal Chemistry - Cardiovascular & Hematological Age;Apr2005, Vol. 3 Issue 2, p105 

    One of the most common causes of drug withdrawal from the market is the prolongation of the QT interval associated with polymorphic ventricular tachycardia or torsade de pointes (TdP) that can degenerate into ventricular fibrillation and sudden cardiac death. Cardiac and non-cardiac drugs...

  • QT Prolongation and Safety in the Indian Population. Dabhi, Jayesh; Mehta, Anita // Current Drug Safety;Sep2007, Vol. 2 Issue 3, p200 

    The QT interval in electrocardiogram (ECG) reflects the total duration of ventricular myocardial depolarization and repolarization. It has been well recognized that many condition may cause QT interval prolongation. Unfortunately, numbers of cardiac and non-cardiac drug prolong the QT interval...

  • Interventional Role of Piperazine Citrate in Barium Chloride Induced Ventricular Arrhythmias in Anaesthetized Rats. Ghasi, S.; Mbah, A. U.; Nze, P. U.; Nwobodo, E.; Ogbonna, A. O.; Onuaguluchi, G. // Biomedical Research (0970-938X);Sep-Dec2009, Vol. 20 Issue 3, p186 

    Interventional potential of piperazine in Barium Chloride (BC) -induced ventricular arrhythmias was investigated in the rats. Various forms of arrhythmias were induced in 10 rats and piperazine (30mg/kg) was given in each case to reverse arrhythmia to sinus rhythm. Five out of six cases of...

  • Classification of Cardiac Arrhythmias with TSK Fuzzy System using Genetic Algorithm. Safdarian, Naser; Maghooli, Keivan; Dabanloo, Nader Jafarnia // International Journal of Signal Processing, Image Processing & P;Jun2012, Vol. 5 Issue 2, p89 

    Detection of cardiac arrhythmias, particularly ventricular fibrillation (VF), and ventricular tachycardia (VT) have been highly regarded and has done several works in this field. In this study, a method based on the Takagi-Sugeno-Kang (TSK) fuzzy system for ECG arrhythmia detection and...

  • Comparative follow up of patients with implanted cardioverter-defibrillators after induction of sustained monomorphic ventricular tachycardias or ventricular fibrillation by programmed stimulation. Meyborg, M.; Mura, R.; Tiefenbacher, C.; Becker, R.; Michaelsen, J.; Niroomand, F. // Heart;Jun2003, Vol. 89 Issue 6, p629 

    Objective: To investigate the prognostic value of induced monomorphic ventricular tachycardia (VT) and ventricular flutter or fibrillation (VF) during programmed electrical stimulation in patients with a high risk for sudden arrhythmogenic cardiac death. Design: Prospective cohort study....

  • Electrical Storms in Patients with an Implantable Cardioverter Defibrillator.  // Yonsei Medical Journal;1/1/2011, Vol. 52 Issue 1, p26 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics