TITLE

Interleukin-12p70--Dependent Interferon-γ Production Is Crucial for Resistance in African Trypanosomiasis

AUTHOR(S)
Barkhuizen, Mark; Magez, Stefan; Atkinson, Robert A.; Brombacher, Frank
PUB. DATE
October 2007
SOURCE
Journal of Infectious Diseases;10/15/2007, Vol. 196 Issue 8, p1253
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
African trypanosomiasis encompasses diseases caused by pathogenic trypanosomes, infecting both humans and animals. In the present article, we dissected the possible role of members of the interleukin (IL)-12 family during infection with Trypanosoma brucei brucei and Trypanosoma evansi in mice. IL-12p35-/-, IL-12p40-/-, and IL-12p35-/-/p40-/- mice were susceptible to both pathogens, as was demonstrated by the increased mortality among these mice, compared with wild-type C57BL/6 mice. The different IL-12p70-/- mouse strains showed similar mortality kinetics, suggesting that IL-12p70—but not the IL-12p80 homodimer or IL-23—plays a crucial role in survival. Although there were similar plasma levels of immunoglobulin (Ig) M and IgG2a in IL-12-deficient mice and wild-type mice, interferon (IFN)-γ production, especially during early infection, was severely impaired in all IL-12p70-/- mouse strains, demonstrating an IL-12p70-dependent mechanism for IFN-γ production. Because IFN-γ receptor-deficient mice (IFN-γR-/-) were also highly susceptible to both Trypanosoma species, IL-12p70-dependent IFN-γ production seems to be the important mechanism involved in resistance against both pathogens.
ACCESSION #
26923566

 

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