Aciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay

Abraham, A. M.; Kavitha, S.; Joseph, P.; George, R.; Pillay, D.; Malathi, J.; Jesudason, M. V.; Sridharan, G.
July 2007
Indian Journal of Medical Microbiology;Jul2007, Vol. 25 Issue 3, p260
Academic Journal
journal article
Resistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 microg/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 microg/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 microg/mL.


Related Articles

  • MANAGEMENT OF GENITAL HERPES INFECTIONS IN HIV INFECTED PATIENTS. Samraj, S; Patel, R // Indian Journal of Dermatology;2006, Vol. 51 Issue 1, p8 

    The article provides information on the management of genital herpes infections in HIV-infected patients. The mechanism of action of antiviral drugs used to treat herpes infections is discussed. There are several antiviral methods for the determination of susceptibility in herpes simplex virus....

  • Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials. Sarisky, R. T.; Bacon, T. H.; Boon, R. J.; Duffy, K. E.; Esser, K. M.; Leary, J.; Locke, L. A.; Nguyen, T. T.; Quail, M. R.; Saltzman, R. // Archives of Virology;Sep2003, Vol. 148 Issue 9, p1757 

    Summary. A susceptibility testing program was established to determine the prevalence of resistance to penciclovir among herpes simplex virus isolates collected from patients participating in 11 world-wide clinical trials involving penciclovir (topical or intravenous formulations) or...

  • Resistance of herpes simplex to acyclovir. Balfour, Jr., Henry H.; Balfour, H H Jr // Annals of Internal Medicine;Mar83, Vol. 98 Issue 3, p404 

    Addresses the problem of resistance of herpes simplex to acyclovir. Information on herpes simplex virus strains; Effectiveness of acyclovir against replicating virus; Mechanisms of resistance of herpes simplex virus to acyclovir.

  • Aciclovir.  // Reactions Weekly;Jul2014, Vol. 1508 Issue 1, p6 

    The article presents a case study of a 28-day-old girl who encountered aciclovir resistance during her medication for Herpes Simplex Virus Type-2 (HSV-2).

  • Aciclovir.  // Reactions Weekly;02/09/2013, Issue 1438, p5 

    The article presents a case study of a male neonate who developed resistance to aciclovir on being treated with the drug for herpes simplex virus type 1 (HSV-1) infection.

  • Aciclovir/cidofovir.  // Reactions Weekly;Feb2015, Vol. 1537 Issue 1, p15 

    The article presents a case study of a 55-year old male patient with HIV who developed extensive genital verrucous herpes simplex virus (HSV) infection, elevated serum creatinine levels, and resistance to aciclovir.

  • Aciclovir able to cost effectively stave off HIV if the price is right.  // PharmacoEconomics & Outcomes News;3/5/2011, Issue 623, p3 

    The article reports on the study "The Cost Effectiveness of Herpes Simplex Virus-2 Suppressive Therapy With Daily Aciclovir for Delaying Progression Among HIV-1 Infected Women in South Africa," by P. Vickerman et al, which found that aciclovir is cost-effective in slowing the progression of HIV-1.

  • Zovirax Cold Sore Cream.  // Royal Society of Medicine: Medicines;2002, p581 

    This article presents information on Zovirax Cold Sore Cream which is a proprietary, non-prescription preparation of the antiviral drug aciclovir. It can be used to treat infection of the lips and face by herpes simplex viruses. It is available as a cream.

  • Keeping tight control of herpes zoster. Morris, David // GP: General Practitioner;1/20/2003, p58 

    Discusses the use of drugs aciclovir, valaciclovir and famciclovir in the treatment of herpes simplex and herpes zoster infections. Function of these drugs; Disadvantages associated with the use of aciclovir; Need of low dose therapy of these drugs for the treatment of genital herpes.

  • New Advances in Anti-HSV Chemotherapy. Superti, F.; Ammendolia, M. G.; Marchetti, M. // Current Medicinal Chemistry;2008, Vol. 15 Issue 9, p900 

    Treatment of human herpes simplex virus (HSV) diseases represents an important goal, as herpetic infections are not controlled by vaccination. Many therapeutic agents have been developed and used for HSV infections and several alternative natural compounds are under investigation. Most of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics