TITLE

Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves’ disease in Chinese patients

AUTHOR(S)
Shu Wang; Hua Sun; Hao-Yan Chen; Ze-Fei Zhao; Yang Yang; Yong-Ju Zhao; Bin Cui; Guang Ning
PUB. DATE
April 2007
SOURCE
Endocrine (1355008X);Apr2007, Vol. 31 Issue 2, p114
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
ObjectiveIn order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves’ disease (GD) and the susceptibility of K469E polymorphism to Graves’ ophthalmopathy (GO) in Chinese population.Study DesignA case-control and replication study was performed in 212 GD patients and 204 healthy subjects to analyze the genotypes. Furthermore the distribution of ICAM-1 genotypes was investigated in subgroups of patients with GD according to the onset age and the ophthalmopathy.ResultsNo G241R polymorphism of ICAM-1 gene was detected in Chinese. No significant differences of allele and genotype frequencies regarding K469E polymorphism were found between GD patients and healthy controls (χ2 = 0.092, P = 0.762; χ2 = 1.089, P = 0.580). In addition, the genotype–phenotype correlation was not identified either.ConclusionsWe found no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of GD in a Chinese population. However, we could not rule out possible contributions of other polymorphisms of the ICAM-1gene to the pathogenesis of GD. Therefore, further studies are needed to elucidate the role of ICAM-1gene in Graves’ disease in different population.
ACCESSION #
26647587

 

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