Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)

Pearce, Neil; Aït-Khaled, Nadia; Beasley, Richard; Mallol, Javier; Keil, Ulrich; Mitchell, Ed; Robertson, Colin
September 2007
Thorax;Sep2007, Vol. 62 Issue 9, p758
Academic Journal
Background: Phase I of the International Study of Asthma and Allergies in Childhood (ISAAC) was designed to allow worldwide comparisons of the prevalence of asthma symptoms. In phase III the phase I survey was repeated in order to assess changes over time. Methods: The phase I survey was repeated after an interval of 5-10 years in 106 centres in 56 countries in children aged 13-14 years (n = 304 679) and in 66 centres in 37 countries in children aged 6-7 years (n=193 404). Results: The mean symptom prevalence of current wheeze in the last 12 months changed slightly from 13.2% to 13.7% in the 13-14 year age group (mean increase of 0.06% per year) and from 11.1% to 11.6% in the 6-7 year age group (mean increase of 0.13% per year). There was also little change in the mean symptom prevalence of severe asthma or the symptom prevalence measured with the asthma video questionnaire. However, the time trends in asthma symptom prevalence showed different regional patterns. In Western Europe, current wheeze decreased by 0.07% per year in children aged 13-14 years but increased by 0.20% per year in children aged 6-7 years. The corresponding findings per year for the other regions in children aged 13-14 years and 6-7 years, respectively, were: Oceania (-0.39% and -0.21%); latin America (+0.32% and +0.07%); Northern and Eastern Europe (+0.26% and +0.05%); Africa (+0.16% and +0.10%); North America (+0.12% and +0.32%); Eastern Mediterranean (-0.10% and +0.79%); Asia-Pacific (+0.07% and -0.06%); and the Indian subcontinent (+0.02% and +0.06%). There was a particularly marked reduction in current asthma symptom prevalence in English language countries (-0.51% and -0.09%). Similar patterns were observed for symptoms of severe asthma. However, the percentage of children reported to have had asthma at some time in their lives increased by 0.28% per year in the 13-14 year age group and by 0.18% per year in the 6-7 year age group. Conclusions: These findings indicate that international differences in asthma symptom prevalence have reduced, particularly in the 13-14 year age group, with decreases in prevalence in English speaking countries and Western Europe and increases in prevalence in regions where prevalence was previously low. Although there was little change in the overall prevalence of current wheeze, the percentage of children reported to have had asthma increased significantly, possibly reflecting greater awareness of this condition and/or changes in diagnostic practice. The increases in asthma symptom prevalence in Africa, Latin America and parts of Asia indicate that the global burden of asthma is continuing to rise, but the global prevalence differences are lessening.


Related Articles

  • Asthma Control and Hospitalizations Among Inner-City Children: Results of a Randomized Trial. Sylvia Guendelman; Kelley Meade; Ying Qing Chen; Mindy Benson // Telemedicine & e-Health;Nov2004 Supplement 2, Vol. 10, pS-6 

    Asthma prevalence is increasing among poor and minority children. We examined the effectivenessof a novel interactive device programmed for self-management of pediatric asthmain reducing asthma control problems and hospitalizations. A randomized controlled trial (66children in the intervention...

  • Identifying Students with Self-Report of Asthma and Respiratory Symptoms in an Urban, High School Setting. Christine Joseph; Alan Baptist; Sonja Stringer; Suzanne Havstad; Dennis Ownby; Christine Johnson; L. Williams; Edward Peterson // Journal of Urban Health;Jan2007, Vol. 84 Issue 1, p60 

    Abstract??Strategies for identifying urban youth with asthma have not been described for high school settings. African-American high school students are rarely included in asthma studies, despite a high risk of asthma mortality when compared to other age and race groups. Identification and...

  • Montelukast vs. Inhaled Low-Dose Budesonide as Monotherapy in the Treatment of Mild Persistent Asthma: A Randomized Double Blind Controlled Trial. Vikram Kumar; P. Ramesh; Rakesh Lodha; R. M. Pandey; S. K. Kabra // Journal of Tropical Pediatrics;Oct2007, Vol. 53 Issue 5, p325 

    Background: Guidelines recommend daily controller therapy for mild persistent asthma. Montelukast has demonstrated consistent benefit in controlling symptoms of asthma and may be an alternative, orally administered, nonsteroidal agent for treating mild asthma. Aim: To determine whether...

  • Genome-wide transcriptional profiling linked to social class in asthma. Chen, E.; Miller, G. E.; Walker, H. A.; Arevalo, J. M.; Sung, C. Y.; Cole, S. W. // Thorax;Jan2009, Vol. 64 Issue 1, p38 

    Objectives: Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. This study tested whether the social...

  • Asthma Prevalence Among Inner-City Asian American Schoolchildren. Lee, Ted; Brugge, Doug; Francis, Charlene; Fisher, Opal // Public Health Reports;May/Jun2003, Vol. 118 Issue 3, p215 

    Presents a study that conducted a cross-sectional survey of the prevalence of asthma among schoolchildren at the Josiah Quincy Elementary School in Boston Chinatown, Massachusetts. Percentage of Asian American students in the school; Methods used; Results of the survey.

  • Superiority of Oral Steroids in Acute Pediatric Asthma. Kirchner, Jeffrey T. // American Family Physician;3/15/2001, Vol. 63 Issue 6, p1203 

    Discusses a study by Schuh and others to compare the efficacy of inhaled fluticasone with oral prednisone in children with severe acute asthma. Description of the study and its results; Conclusion that oral prednisone is superior to inhaled fluticasone in the treatment of children with acute...

  • Cough Variant Asthma: Lessons Learned from Deep Inspirations. Lougheed, M.; Turcotte, Scott; Fisher, Thomas // Lung;Feb2012, Vol. 190 Issue 1, p17 

    The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations...

  • Quick guide to...  // Children & Young People Now (Haymarket Business Publications Ltd;4/9/2009, p23 

    The article offers information on asthma, a condition that causes the airways of the lungs to become inflamed and swollen. It states that causes of asthma is believed to be both of genetic and environmental factors. It determines that asthma attack can be life threatening and needs hospital...

  • Associations between Nasal Torquetenovirus Load and Spirometric Indices in Children with Asthma. Pifferi, Massimo; Maggi, Fabrizio; Andreoli, Elisabetta; Lanini, Letizia; de Marco, Emanuela; Fornai, Claudia; Vatteroni, Maria Linda; Pistello, Mauro; Ragazzo, Vincenzo; Macchia, Pierantonio; Boner, Attilio; Bendinelli, Mauro // Journal of Infectious Diseases;10/1/2005, Vol. 192 Issue 7, p1141 

    Fifty-nine children with well-controlled, mild to moderate persistent asthma were studied for the presence and load of torquetenovirus (TTV) in nasal fluid. Rates of TTV positivity and mean nasal TTV loads were not dissimilar to those observed in the general population and in a group of 30 age-...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics