TITLE

Low bone mineral density and fracture burden in postmenopausal women

AUTHOR(S)
Cranney, Ann; Jamal, Sophie A.; Tsang, James F.; Josse, Robert G.; Leslie, William D.
PUB. DATE
September 2007
SOURCE
CMAJ: Canadian Medical Association Journal;9/11/2007, Vol. 177 Issue 6, p575
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The study objectives were to determine fracture rates in relation to bone mineral density at various central skeletal sites, using the World Health Organization definition for osteoporosis (T-score -2.5 or less), and to contrast fracture patterns among women 50 to 64 years of age with those among women 65 years of age and older. Methods: Historical cohort study with a mean observation period of 3.2 (standard deviation [SD] 1.5) years. The study group (16 505 women 50 years of age or older) was drawn from the Manitoba Bone Density Program database, which includes all bone mineral density results for Manitoba. Baseline density measurements for the lumbar spine and hip were performed with dual-energy x-ray absorptiometry. Outcomes included the percentage of osteoporotic fractures and the rates of fracture and excess fracture (per 1000 person-years) among postmenopausal women with osteopenia and osteoporosis relative to those with normal bone mineral density (according to the classification of the World Health Organization). Results: The mean age was 65 (SD 9) years, and the mean Tscores for all sites fell within the osteopenic category. There were 765 incident fractures (fracture rate 14.5 [95% confidence interval, CI, 13.5-15.6 [per 1000 person-years). Fracture rates were significantly higher among women 65 years of age or older than among women 50-64 years of age (21.6 [95% CI 19.7- 23.4] v. 8.6 [95% CI 7.5-9.7] per 1000 person-years, p< 0.001). Although fracture rates were significantly higher among women with osteoporotic T-scores, most fractures occurred in women with nonosteoporotic values (min-max: 59.7%-67.8%). Interpretation: In this study, most of the postmenopausal women with osteoporotic fractures had nonosteoporotic bone mineral density values. This finding highlights the importance of considering key clinical risk factors that operate independently of bone mineral density (such as age) when assessing fracture risk.
ACCESSION #
26595523

 

Related Articles

  • Epidemic of undiagnosed osteopenia in postmenopausal women.  // Contemporary OB/GYN;Apr2002, Vol. 47 Issue 4, p27 

    Presents the results of a study on the fracture outcomes of undiagnosed low bone mineral density in postmenopausal women. Link between postmenopausal women and the occurrence of undiagnosed osteopenia; Increased risk for fractures in women with osteopenia; Comparison between the fracture rate...

  • No long-term benefit shown for bones after HRT. Yates, J.; Barrett-Connor, E.; Barlas, S.; Chen, Y. T.; Miller, P. D.; Siris, E. S. // BMJ: British Medical Journal (International Edition);7/3/2004, Vol. 329 Issue 7456, preceding p1 

    Presents an abstract of a medical study to evaluate whether hormone replacement therapy continues to provide protection from hip fractures after the treatment is stopped. Report on the national osteoporosis risk assessment study for postmenopausal women; Conclusion that women taking short term...

  • ANALIZA PARAMETRILOR OSOSI SI DE ULTRASONOGRAFIE CALCANEANA LA PACIENTELE CU OSTEOPENIE DE POSTMENOPAUZA. Carsote, Mara; Ene, Cristina; Radoi, Valentin; Voicu, Gabriela; Coculescu, Mihail; Poiana, Catalina // Romanian Journal of Rheumatology;2012, Vol. 21 Issue 1, p38 

    We present a transversal study in 306 anti-osteoporotic free medication, postmenopausal women, who were analyzed based on DXA. The 153 patients with osteopenia were statistically significant different from those 103 with normal DXA by following parameters: body mass index, bone formation marker...

  • The Assessment of Bone Mass in Men. Lombardi, A.; Ross, P.D. // Calcified Tissue International;Oct2001, Vol. 69 Issue 4, p222 

    Bone mineral density (BMD) is widely used in postmenopausal women to identify who should be given therapy for prevention and treatment of osteoporosis and to monitor the efficacy of treatment. There is still uncertainty about how to interpret BMD in men, and few prospective studies exist on the...

  • Muscle Strength and Body Composition Are Clinical Indicators of Osteoporosis. Rikkonen, Toni; Sirola, Joonas; Salovaara, Kari; Tuppurainen, Marjo; Jurvelin, Jukka; Honkanen, Risto; Kröger, Heikki // Calcified Tissue International;Aug2012, Vol. 91 Issue 2, p131 

    We examined the role of muscle strength, lean tissue distribution, and overall body composition as indicators of osteoporosis (OP) in a pooled sample of 979 Finnish postmenopausal women (mean age 68.1 years) from the Kuopio Osteoporosis Risk Factor and Prevention study. Bone mineral density...

  • Funding threat to prescribing plan.  // Pulse;5/17/2004, Vol. 64 Issue 20, p17 

    Reports on criticisms against the National Institute for Clinical Excellence for releasing confusing guidelines on the secondary prevention of bone fractures in postmenopausal women. Initial recommendations on osteoporosis.

  • Osteoporosis a preventable menopausal concern. BASSENT, YVETTE // Charlotte Post;10/6/2011, Vol. 37 Issue 4, p1B 

    The article offers information on the manifestation of osteoporosis and osteopenia among menopausal women and how they can be prevented.

  • Reporting of vertebral fractures on spine X-rays. Fechtenbaum, J.; Cropet, C.; Kolta, S.; Verdoncq, B.; Orcel, P.; Roux, C. // Osteoporosis International;Dec2005, Vol. 16 Issue 12, p1823 

    Vertebral fractures are the hallmark of osteoporosis, responsible for increased morbidity and mortality in post-menopausal women. However, two-thirds of vertebral fractures do not come to clinical attention. The aim of this study was to compare the identification of vertebral fractures on spine...

  • Can peripheral DXA measurements be used to predict fractures in elderly women living in the community? Barr, R. J.; Adebajo, A.; Fraser, W. D.; Halsey, J. P.; Kelsey, C.; Stewart, A.; Reid, D. M. // Osteoporosis International;Oct2005, Vol. 16 Issue 10, p1177 

    While axial dual energy X-ray absorptiometry (DXA) is the accepted ‘gold standard’ method both for diagnosing osteoporosis and predicting fractures, appropriate equipment is not universally available. Peripheral bone mass measurements may have the potential to identify patients at...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics