TITLE

Diabetes drug pioglitazone (Actos): risk of fracture

AUTHOR(S)
Meymeh, Reza Heidarpour; Wooltorton, Eric
PUB. DATE
September 2007
SOURCE
CMAJ: Canadian Medical Association Journal;9/25/2007, Vol. 177 Issue 7, p723
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the drug pioglitazone which is used as monotherapy or combination therapy for type 2 diabetes mellitus. It states that the people who use this drug are more prone to have bone fracture. The drug is a thiazolidinedione (TZD) which activates perioxisome proliferator-activated receptors (PPAR) which shoot glucose utilization and reduce glucose production by the liver, and increase insulin sensitivity in adipose and muscle tissue. It can also contribute to the risk factors for osteoporosis in women.
ACCESSION #
26594454

 

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