TITLE

Acid-Suppressive Effects of Various Regimens of Omeprazole in Helicobacter pylori -Negative CYP2C19 Homozygous Extensive Metabolizers: Which Regimen Has the Strongest Effect?

AUTHOR(S)
Tomohiko Shimatani; Tomoko Kuroiwa; Mutsuko Moriwaki; Jing Xu; Susumu Tazuma; Masaki Inoue
PUB. DATE
October 2007
SOURCE
Digestive Diseases & Sciences;Oct2007, Vol. 52 Issue 10, p2826
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  To achieve more potent and long-lasting acid suppression, omeprazole was administered for 7 days in 5 regimens: 10, 20, and 40 mg once daily (od), and 10 and 20 mg twice daily (bid), in 7 healthy Helicobacter pylori-negative CYP2C19 homozygous extensive metabolizers, and intragastric pH was continuously measured. The median intragastric pH and percent time pH > 4.0 for 24 hours increased dose dependently with 10, 20, and 40 mg od. Ten and 20 mg bid wre comparable to 20 and 40 mg od, respectively. Concerning percent time pH > 4.0 in the nighttime (20:00–8:00 hours), 20 mg bid was significantly superior to 40 mg od (P 
ACCESSION #
26588670

 

Related Articles

  • Eradication of H. pylori in a Developing Country: Comparison of Lansoprazole Versus Omeprazole with Norfloxacin, in a Dual-Therapy Study. Gupta, V. K.; Dhar, A.; Srinivasan, S.; Rattan, A.; Sharma, M. P. // American Journal of Gastroenterology;Jul1997, Vol. 92 Issue 7, p1140 

    Objectives: Lansoprazole, a newer benzimidazole, is more potent than omeprazole in its anti-Helicobacter pylori effect in vitro. The present study was aimed at assessing its efficacy in a developing country. Methods: Fifty patients were randomized to receive either lansoprazole...

  • Helicobacter pylori Does Not Migrate from the Antrum to the Corpus in Response to Omeprazole. Graham, David Y.; Genta, Robert; Evans, Dolores G.; Reddy, Rita; Clarridge, Jill E.; Olson, Carol A.; Edmonds, A. L.; Siepman, Nancy // American Journal of Gastroenterology;Oct1996, Vol. 91 Issue 10, p2102 

    Background: Omeprazole is known to have an effect on Helicobacter pylori in vivo. One opinion is that H. pylori "migrates" from the antrum to the corpus in response to omeprazole therapy. Methods: To determine whether H. pylori migrates in response to omeprazole, we...

  • Which Has Superior Acid-Suppressive Effect, 10 Mg Omeprazole Once Daily or 20 Mg Famotidine Twice Daily? Effects of Single or Repeated Administration in Japanese Helicobacter Pylori-Negative CYP2C19 Extensive Metabolizers. Tomohiko Shimatani; Masaki Inoue; Tomoko Kuroiwa; Mutsuko Moriwaki; Jing Xu; Kazuro Ikawa; Norifumi Morikawa; Susumu Tazuma // Digestive Diseases & Sciences;Feb2007, Vol. 52 Issue 2, p390 

    Abstract??Low-dose omeprazole is superior to full-dose famotidine in maintenance therapy for gastroesophageal reflux disease, whereas ?on-demand? famotidine is more effective for relief of episodes of heartburn. To explain this apparent discrepancy, intragastric pH was measured for 24-hr seven...

  • Medium-Term Results of Oral and Intravenous Omeprazole/ Amoxicillin Helicobacter pylori Eradication Therapy. Adamek, Romuald J.; Wegener, Martin; Labenz, Joachim; Freitag, Maren; Opferkuch, Wolfgang; Rühl, Georg H. // American Journal of Gastroenterology;Jan1994, Vol. 89 Issue 1, p39 

    Objectives: The aim of the present study was to examine the effect of the application route of the antibiotic amoxicillin in Helicobacter pylori eradication, using omeprazole/amoxicillin. Methods: In a prospective medium-term study, 31 patients with H....

  • Second-line and Rescue Therapies for Helicobacter pylori Eradication in Clinical Practice. Zullo, Angelo; De Francesco, Vincenzo; Manes, Gianpiero; Scaccianoce, Giuseppe; Cristofari, Francesca; Hassan, Cesare // Journal of Gastrointestinal & Liver Diseases;Jun2010, Vol. 19 Issue 2, p131 

    Background & Aims. A levofloxacin-based triple therapy and a rifabutin-based regimen are advised as second-line and rescue therapies in the current Italian guidelines for H. pylori eradication. However, no data are available for the efficacy of these treatments in clinical practice. Methods. A...

  • Bismuth-free Triple Therapy for Eradicating Helicobacter pylori and Reducing the Gastric Ulcer Recurrence Rate. Karita, Mikio; Morshed, M. G.; Ouchi, Kazunobe; Okita, Kiwamu // American Journal of Gastroenterology;Jul1994, Vol. 89 Issue 7, p1032 

    Objectives: The goals of this study were to assess the effectiveness of a new triple therapy consisting of amoxicillin and metronidazole with plaunotol in the eradication of Helicobacter pylori infection in humans, and to determine whether this treatment regimen reduces the rate of recurrence of...

  • Therapeutic Options after Failed Helicobacter pylori Eradication Therapy. Van der Hulst, R. W. M.; Weel, J. F. L.; Van der Ende, A.; Ten Kate, F. J. W.; Dankert, J.; Tytgat, G. N. J. // American Journal of Gastroenterology;Nov1996, Vol. 91 Issue 11, p2333 

    Objectives: Many of the currently used Helicobacter pylori eradication regimens fail to cure 5-20% of the patients. Those patients will remain at risk of developing a potentially fatal complication of peptic ulcer disease. Therefore, a new attempt to cure H. pylori infection after initial...

  • Empirical prescribing for dyspepsia: randomised controlled trial of test and treat versus omeprazole treatment. Manes, Gianpiero; Menchise, Antonella; de Nucci, Claudio; Balzano, Antonio // BMJ: British Medical Journal (International Edition);5/24/2003, Vol. 326 Issue 7399, p1118 

    Abstract Objective To compare the efficacy of a "Helicobacter pylori test and treat" strategy with that of an empirical trial of omeprazole in the non-endoscopic management by empirical prescribing of young patients with dyspepsia. Design Randomised controlled trial. Setting Hospital...

  • Efficacy of Omeprazole One Year after Cure of Helicobacter pylori Infection in Duodenal Ulcer Patients. Labenz, Joachim; Tillenburg, Birgit; Peitz, Ulrich; Börsch, Gereon; Idström, Jan-Peter; Verdú, Elena; Stolte, Manfred; Blum, Andrée L. // American Journal of Gastroenterology;Apr1997, Vol. 92 Issue 4, p576 

    Objective: We have previously shown that, in duodenal ulcer patients, pH control by omeprazole is less pronounced after cure of Helicobacter pylori infection. The present study was designed to test the hypothesis that this response to omeprazole persists 1 yr after cure of H. pylori infection....