Pilot Studies to Demonstrate That Intestinal Mucosal Afferent Nerves Are Functionally Linked to Visceral Adipose Tissue

Andre Obenaus; Joseph Leung
October 2007
Digestive Diseases & Sciences;Oct2007, Vol. 52 Issue 10, p2695
Academic Journal
Abstract  Dietary capsaicin reduces rodent visceral fat weight. We tested the hypothesis that intact intestinal mucosal afferent nerve function is necessary for fat deposition in visceral adipose tissue sites. Rats were treated daily for 2 weeks with intragastric (chronic treatment) vehicle or capsaicin. Superior mesenteric artery blood flow and mesenteric and inguinal fat blood flow were measured before and after capsaicin was administered into the duodenum (acute treatment). Fat from all sites was dissected and weighed. Chronic capsaicin significantly attenuated acute capsaicin-induced mesenteric hyperemia but did not abolish the reflex wiping of the eye exposed to capsaicin, indicating that functional ablation was limited to the intestinal mucosal afferent nerves. The associated vasoconstriction in adipose tissue was inhibited at the visceral (mesenteric) site and maintained but attenuated at the subcutaneous (inguinal) site. The onset of vasoconstriction was instantaneous, indicating a reflex mechanism. There was a redistribution of fat from visceral to subcutaneous sites, reflected by a decrease and an increase in the percentage of body fat in the visceral and subcutaneous sites, respectively. These pilot studies reveal for the first time that normal intestinal mucosal afferent nerve function is necessary for the physiologic accumulation of fat in visceral adipose tissue sites.


Related Articles

  • Mesenteric panniculitis: Case report and literature review. Parra-Davila, Eduardo; McKenney, Mark G.; Sleeman, Danny; Hartmann, Rene; Rao, Rajeev K.; McKenney, Kimberley; Compton, Raymond P. // American Surgeon;Aug1998, Vol. 64 Issue 8, p768 

    Describes a medical case of mesenteric panniculitis. Inflammatory condition of the adipose tissue of unknown etiology; Replacement of mesentery with fibrosis; Medical background of patient studied; Identification of mesenteric panniculitis as a stage of sclerosing mesenteritis; Retractile...

  • Altered Expression of BK Channel β1 Subunit in Vascular Tissues from Spontaneously Hypertensive Rats Chang, Tuanjie; Wu, Lingyun; Wang, Rui // American Journal of Hypertension;Jul2006, Vol. 19 Issue 7, p678 

    Correlation of blood pressure (BP) with expression levels of large-conductance, voltage- and Ca2+-activated K+ (BK) channel β1 subunit in vascular tissues from spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD) at different ages was investigated....

  • Segmental arterial mediolysis accompanied by renal infarction and pancreatic enlargement: a case report. Ito, Nobuhisa; Kuwahara, Go; Sukehiro, Yuta; Teratani, Hiromitsu // Journal of Medical Case Reports;2012, Vol. 6 Issue 1, p307 

    Introduction: Due to recent advances in imaging diagnostic techniques, there are an increasing number of case reports of segmental arterial mediolysis. However, there are only a limited number of reports on segmental arterial mediolysis-related abnormalities of abdominal organs other than the...

  • Mesenteric Panniculitis: A Case Report and Review of the Literature. GUNDUZ, Yasemin; TATLI, Lacin; KARA, Rabia Oztas // Maedica - a Journal of Clinical Medicine;2012, Vol. 7 Issue 4, p344 

    Mesenteric panniculitis is a benign disease characterized chronic nonspecific inflammation of the mesentery adipose tissue of the small intestine and colon. The specific etiology of the disease is unknown. The diagnosis is suggested by computed tomography (CT) and is usually confirmed by...

  • Perivascular adipose tissue-mediated anti-contractile effects in mouse first order mesenteric arteries. Thakore, P.; Aubdool, A. A.; Brain, S. D.; McFadzean, I. // Proceedings of the Physiological Society;2014, p196P 

    An abstract of the article "Perivascular adipose tissue-mediated anti-contractile effects in mouse first order mesenteric arteries" by P. Thakore, A. A. Aubdool, S. D. Brain and I. McFadzean is presented.

  • Peripancreatic lymphatic invasion by pancreatic carcinoma: evaluation with multi-detector row CT. Sai, Michiaki; Mori, Hiromu; Kiyonaga, Maki; Kosen, Kazuhisa; Yamada, Yasunari; Matsumoto, Shunro // Abdominal Imaging;Apr2010, Vol. 35 Issue 2, p154 

    Peripancreatic lymphatic networks are frequently involved in pancreatobiliary carcinoma, affecting the prognosis. However, little attention has been paid to CT imaging of normal and pathological conditions of peripancreatic lymphatic networks. We evaluated multi-detector row CT (MDCT) images of...

  • DID YOU KNOW?  // Women's Fitness;Aug2014, Issue 130, p89 

    The article discusses the tips from skin expert Jill Zander, regarding swimming and running being the best exercise for increasing blood circulation and loosing fat tissues, and cellulite whooping women.

  • Acute Mesenteric Ischemia: A Simple and Practical Approach. Samuels, Louis E.; Gensler, Todd W.; Kerstein, Morris D. // Vascular Surgery;May1992, Vol. 26 Issue 4, p272 

    The diagnosis and management of acute mesenteric ischemia (AMI) have evolved considerably since first described nearly 150 years ago. Angiography remains the gold standard for establishing a definitive diagnosis. Today, several therapeutic options--both percutaneous and surgical--are available...

  • Mesenteric Ischemia. Ujiki, Michael; Kibbe, Melina R. // Perspectives in Vascular Surgery & Endovascular Therapy;Dec2005, Vol. 17 Issue 4, p309 

    Mesenteric ischemia is a morbid, potentially life-threatening disease that is associated with a relatively high mortality, often due to its late diagnosis. Currently, the incidence of mesenteric ischemia in the United States is low; however, the incidence is predicted to increase because of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics