Age and Indication for Referral to Capsule Endoscopy Significantly Affect Small Bowel Transit Times: The Given Database

Shosh Friedman; Hagit Ephrath; Eran Choman; Hila Debby
October 2007
Digestive Diseases & Sciences;Oct2007, Vol. 52 Issue 10, p2884
Academic Journal
Abstract  The purpose of this study was to examine the effect of age and selected indications for capsule endoscopy on small bowel transit times. Data on 67 clinical studies (790 subjects with different gastrointestinal pathologies [49.5% males; mean age, 51.9 � 18.33 years; range, 18–91 years] and 87 healthy volunteers) were retrieved from the company (Given Imaging, Ltd.)-sponsored database. All subjects swallowed the PillCam SB Capsule after a 12-hr fast. The capsule reached the cecum in all 877 participants. Indications for referral for capsule endoscopy were as follows: 372 obscure gastrointestinal bleeding, 96 suspected Crohn’s disease, 65 celiac disease, 54 irritable bowel syndrome, and 116 familial adenomatous polyposis, intestinal lymphoma, or ulcerative colitis. One group consisted of patients n = 235), and the other patients 40 years old (n = 555). The younger group, volunteers, and Crohn’s disease patients had significantly shorter small bowel transit times than the others (P 


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