TITLE

Demonstration of Low-Regulatory CD25HighCD4 and High-Pro-inflammatory CD28−CD4 T-Cell Subsets in Patients with Ulcerative Colitis: Modified by Selective Granulocyte and Monocyte

AUTHOR(S)
Yoko Yokoyama; Ken Fukunaga; Yoshihiro Fukuda; Katsuyuki Tozawa; Koji Kamikozuru; Kunio Ohnishi; Takeshi Kusaka; Tadashi Kosaka; Nobuyuki Hida; Yoshio Ohda; Hiroto Miwa; Takayuki Matsumoto
PUB. DATE
October 2007
SOURCE
Digestive Diseases & Sciences;Oct2007, Vol. 52 Issue 10, p2725
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Low-CD25High࠾, a subset of regulatory CD25࠾ T cells and high-inflammatory CD28−CD4 T cells can exacerbate ulcerative colitis (UC). This study sought to investigate the frequency of CD25High࠾ and CD28−CD4 T cells in patients with UC and the changes in these cells during Adacolumn granulocyte and monocyte adsorption apheresis (GMA). Subjects were 12 patients with active UC, 11 with quiescent UC, and 14 healthy volunteers (HVs). The mean clinical activity index was 15.7 � 2.2 in active UC and 4.5 � 1.1 in quiescent UC. Peripheral blood samples were stained with CD4, CD25, and CD28 antibodies for flow cytometry. Patients with active UC received GMA and blood samples were examined before and after the first GMA session. Patients with active UC (P P −D4 cells compared with HVs, while the percentage of CD28࠾ T cells was lower in both UC groups compared with HVs (P = 0.03 and P High࠾ cells compared with quiescent UC patients (P High࠾ T cells was associated with GMA (P High࠾ and high CD28−CD4 are prominent features in UC. The increase in CD25High࠾ T cells induced by GMA should contribute to improved immune function. Additional studies are warranted, since a low frequency of CD25High࠾ − and a high frequency of CD28−CD4 − expressing T cells might be a predictor of clinical response to GMA.
ACCESSION #
26588645

 

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