Effects of Hepatitis C-Induced Liver Fibrosis on Survival in Kidney Transplant Candidates

Emma Furth
October 2007
Digestive Diseases & Sciences;Oct2007, Vol. 52 Issue 10, p2501
Academic Journal
Abstract  We sought to investigate survival among kidney transplant candidates with varying degrees of liver fibrosis. We studied 108 patients with hepatitis C who underwent pre-kidney transplant liver biopsy (1992–2004). Eighteen patients had advanced fibrosis (bridging fibrosis or cirrhosis), and 90 had lesser degrees of fibrosis. Advanced fibrosis patients were younger and had lower prevalence of diabetes. Survival was similar between those with and without advanced fibrosis among all 108 patients (P = 0.92) and among the 58 patients who underwent kidney transplantation (P = 0.83). Fibrosis stage was associated with a 1.1 (0.72, 1.7; P = 0.65) adjusted hazards ratio for mortality among all 108 patients and a 0.64 (0.24, 1.73; P = 0.38) adjusted hazards ratio among the 58 patients who underwent kidney transplantation. These data support the premise that non-liver disease comorbidities are more important outcome determinants in this population. Kidney transplantation alone may be considered in patients with hepatitis C with compensated cirrhosis or bridging fibrosis.


Related Articles

  • Outcome of HCV infection after renal transplantation. Goffin, Eric; Pirson, Yves; Cornu, Chantal; Geubel, André; Squifflet, Jean-Paul; van Ypersele de Strihou, Charles // Kidney International;Feb1994, Vol. 45 Issue 2, p551 

    The fate and significance of hepatitis C virus (HCV) infection after renal transplantation (TP) remain debated. We therefore evaluated the incidence and outcome of HCV infection in 120 kidney graft recipients both at the time of TP and 54 ± 28 (13 to 123) months later using ELISA-II and...

  • Transplantation of kidneys from donors with hepatitis C antibody into recipients with pre-transplantation anti-HCV. Morales, Jose M.; Campistol, Jose M.; Castellano, Gregorio; Andres, Amando; Colina, Francisco; Fuertes, Antonio; Ercilla, Guadalupe; Bruguera, Miguel; Andreu, Jordi; Carretero, Pablo; Rodicio, Jose L.; Levey, Andrew S.; Pereira, Brian J. G. // Kidney International;Jan1995, Vol. 47 Issue 1, p236 

    Hepatitis C virus (HCV) is transmitted by organ transplantation. Consequently, several organ pro- curement organizations have imposed a moratorium on use of organs from anti-HCV positive donors. Because of the inadequate supply of cadaver kidneys for transplantation, we adopted a policy to...

  • Transplantation.  // Kidney;May/Jun2004, Vol. 13 Issue 3, p133 

    Presents several abstracts about medical transplantation. "Long-Term Outcome of Renal Transplantation in Light-Chain Deposition Disease"; "The Impact of Hepatitis C Virus Viremia on Renal Graft and Patient Survival: A 9-Year Prospective Study"; "The Impact of Sirolimus, Mycophenolate Mofetil,...

  • More than half of kidneys from HCV positive donors needlessly discarded.  // Transplant News;Apr2010, Vol. 20 Issue 4, p6 

    The article focuses on the study conducted by Johns Hopkins University regarding Hepatitis C positive organs in the U.S. It states that more than 50 percent of kidneys donations coming from patients infected with Hepatitis C are inappropriately discarded, however, research found out that such...

  • E. Transplantation.  // Kidney;Jul/Aug2006, Vol. 15 Issue 4, p183 

    The article presents summaries of research on medical transplantation. They include "The Role of Pretransplantation Renal Replacement Therapy Modality in Kidney Allograft and Recipient Survival," by J. F. Hurdle et al, "Transmission of Hepatitis C Virus to Several Organ and Tissue Recipients...

  • What Kind of Information About Marginal Donors Is Available Through Sources Other Than Health Care Professionals for Patients on the Waiting List for Organ Transplantation? Kamran, Sara; Calmus, Yvon; Pomey, Marie Pascale; Vidal-Trécan, Gwenaëlle // Journal of Medical Internet Research;Jul2015, Vol. 17 Issue 7, p1 

    Background: The current organ shortage has necessitated expanding the criteria for potential donations to marginal donors (older or sick donors whose organs would have been considered unsuitable before). In France, physicians are not required to provide information to recipients about marginal...

  • Hepatitis C Virus Transmission to Organ and Tissue Recipients.  // Annals of Internal Medicine;11/1/2005, Vol. 143 Issue 9, pI86 

    The article presents information about the study related to the Hepatitis C virus transmission to organ and tissue recipients. Transplantation of organs and tissues from healthy donors or cadavers (dead bodies) to people whose bodies have been damaged by disease, injury, or wear and tear has...

  • Transplantation Outcomes in Patients with Hepatitis C. Sadovsky, Richard // American Family Physician;3/1/2002, Vol. 65 Issue 5, p966 

    Presents information from a study by R.M. Ghobrial and others on the long-term clinical outcomes of patients who received a first-time transplant for end-stage hepatitis C virus-induced liver disease. Description of the study and its results; Conclusion that models can be developed to predict...

  • Quality of life after liver transplantation for hepatitis C infection. Dudley, Tracey; Chaplin, Dawn; Clifford, Collette; Mutimer, David; Mutimer, David John // Quality of Life Research;Oct2007, Vol. 16 Issue 8, p1299 

    Introduction: Transplantation is a life-saving option for patients with liver disease. However, recovery is variable. Impairments in physical health, emotional wellbeing and quality of life are reported. Quality of life may be worse after transplantation for hepatitis C virus (HCV)...


Read the Article


Sign out of this library

Other Topics