TITLE

Role of heregulin in human cancer

AUTHOR(S)
Breuleux, M.
PUB. DATE
September 2007
SOURCE
Cellular & Molecular Life Sciences;Sep2007, Vol. 64 Issue 18, p2358
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor tyrosine kinases, is involved in cell proliferation, invasion, survival and differentiation of normal and malignant tissues. The HRG gene family consists of four members: HRG-1, HRG-2, HRG-3 and HRG-4, of which a multitude of different isoforms are synthesized by alternative exon splicing, showing various tissue distribution and biological activities. Disruption of the physiological balance between HRG ligands and their ErbB receptors is implicated in the formation of a variety of human cancers. The general mechanisms involved in HRG-induced tumorigenesis is discussed.
ACCESSION #
26530275

 

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