TITLE

Very prematurely born infants wheezing at follow-up: lung function and risk factors

AUTHOR(S)
Broughton, Simon; Thomas, Mark R.; Marston, Louise; Calvert, Sandra A.; Marlow, Neil; Peacock, Janet L.; Rafferty, Gerrard F.; Greenough, Anne
PUB. DATE
September 2007
SOURCE
Archives of Disease in Childhood;Sep2007, Vol. 92 Issue 9, p776
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze. Design: Lung function data obtained at 1 year of age were collated From two cohorts of infants recruited into the UKOS and an RSV study, respectively. Setting: Infant pulmonary function laboratory. Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks). Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze. Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpIeth and tidal breathing parameters (TPTEF:TE). Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpIeth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHE:FRCpIeth were significantly associated with wheeze. Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.
ACCESSION #
26522960

 

Related Articles

  • Abnormalities in pulmonary function in infants with high-risk congenital diaphragmatic hernia. Rygl, Michal; Rounova, Petra; Sulc, Jan; Slaby, Krystof; Stranak, Zbynek; Pycha, Karel; Svobodova, Tamara; Pohunek, Petr; Skaba, Richard // Biomedical Papers of the Medical Faculty of Palacky University i;Sep2015, Vol. 159 Issue 3, p497 

    No abstract available.

  • Midtrimester preterm prelabour rupture of membranes (PPROM): expectant management or amnioinfusion for improving perinatal outcomes (PPROMEXIL – III trial). van Teeffelen, Augustinus S. P.; van der Ham, David P.; Willekes, Christine; Al Nasiry, Salwan; Nijhuis, Jan G.; van Kuijk, Sander; Schuyt, Ewoud; Mulder, Twan L. M.; Franssen, Maureen T. M.; Oepkes, Dick; Jansen, Fenna A. R.; Woiski, Mallory D.; Bekker, Mireille N.; Bax, Caroline J.; Porath, Martina M.; de Laat, Monique W. M.; Mol, Ben W.; Pajkrt, Eva // BMC Pregnancy & Childbirth;2014, Vol. 14 Issue 1, p1 

    Background Babies born after midtrimester preterm prelabour rupture of membranes (PPROM) are at risk to develop neonatal pulmonary hypoplasia. Perinatal mortality and morbidity after this complication is high. Oligohydramnios in the midtrimester following PPROM is considered to cause a delay in...

  • Pulmonary haemorrhage in preterm infants. Finlay, Eric R.; Subhedar, Nimish V.; Finlay, E R; Subhedar, N V // European Journal of Pediatrics;2000, Vol. 159 Issue 11, p870 

    Presents a study that aimed to redefine potentially important antenatal and post-natal risk factors associated with pulmonary hemorrhage (PH) in a contemporary neonatal population. Perinatal characteristics and neonatal management of infants with PH and controls; Three factors that were found...

  • Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants. Nguyen, Thanh-Diem; Thia, Lena P.; Ah-Fong Hoo; Bush, Andrew; Aurora, Paul; Wade, Angie; Chudleigh, Jane; Lum, Sooky; Stocks, Janet // Thorax;Oct2014, Vol. 69 Issue 10, p910 

    Rationale Newborn screening (NBS) for cystic fibrosis (CF) allows early intervention. Design of randomised controlled trials (RCT) is currently impeded by uncertainty regarding evolution of lung function, an important trial end point in such infants. Objective To assess changes in pulmonary...

  • Lung function in very preterm infants with patent ductus arteriosus under conservative management: an observational study. Hsiu-Lin Chen; Rei-Cheng Yang; Wei-Te Lee; Pei-Lun Lee; Jong-Hau Hsu; Jiunn-Ren Wu; Zen-Kong Dai; Chen, Hsiu-Lin; Yang, Rei-Cheng; Lee, Wei-Te; Lee, Pei-Lun; Hsu, Jong-Hau; Wu, Jiunn-Ren; Dai, Zen-Kong // BMC Pediatrics;10/24/2015, Vol. 15, p1 

    Background: Persistent patent ductus arteriosus (PDA) during hospitalization is thought to be associated with adverse pulmonary outcomes in very preterm infants. This observational study aimed to compare the lung function in very preterm infants with and without PDA at...

  • Mortality Risk After Neonatal Seizures in Very Preterm Newborns. Pisani, Francesco; Copioli, Cristiana; Turco, Emanuela Claudia; Sisti, Lisa; Cossu, Giuseppe; Seri, Stefano // Journal of Child Neurology;Oct2012, Vol. 27 Issue 10, p1264 

    We analyzed clinical and instrumental data of 403 consecutive newborns with gestational age from 24 to 32 weeks, admitted to the University-Hospital of Parma between January 2000 and December 2007, to evaluate the possible relationship between neonatal mortality and occurrence of neonatal...

  • Postnatally acquired cytomegalovirus infection in preterm infants: a prospective study on risk factors and cranial ultrasound findings. Nijman, Joppe; De Vries, Linda S.; Koopman-Esseboom, Corine; Uiterwaal, Cuno S. P. M.; Van Loon, Anton M.; Verboon-Maciolek, Malgorzata A. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jul2012, Vol. 97 Issue 4, pF259 

    Objective To study risk factors and cranial ultrasound (cUS) fi ndings in a large cohort of preterm infants, admitted to a neonatal intensive care unit and diagnosed with postnatally acquired cytomegalovirus (CMV) infection. Study design This prospective, observational study was performed from...

  • Reduced renal length and volume 20 years after very preterm birth. Keijzer-Veen, Mandy; Devos, Annick; Meradji, Morteza; Dekker, Friedo; Nauta, Jeroen; Heijden, Bert // Pediatric Nephrology;Mar2010, Vol. 25 Issue 3, p499 

    Intrauterine growth retardation is presumed to be associated with decreased renal size and impaired renal function as a result of stunted kidney development and nephron deficit. To study whether very preterm birth also affects renal size at young adulthood, we sonographically measured bipolar...

  • Sudden Infant Death Syndrome among Extremely Preterm Infants: United States 1997-1999. Malloy, Michael H. // Journal of Perinatology;Mar2004, Vol. 24 Issue 3, p181 

    BACKGROUND:: Preterm infants have been reported to be at higher risk than term infants for sudden infant death syndrome (SIDS). Reasons for this higher risk are not clear. OBJECTIVE:: The objective of this study was to analyze medical and demographic characteristics among infants 24 to 32 weeks...

Share

Other Topics