Very prematurely born infants wheezing at follow-up: lung function and risk factors

Broughton, Simon; Thomas, Mark R.; Marston, Louise; Calvert, Sandra A.; Marlow, Neil; Peacock, Janet L.; Rafferty, Gerrard F.; Greenough, Anne
September 2007
Archives of Disease in Childhood;Sep2007, Vol. 92 Issue 9, p776
Academic Journal
Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze. Design: Lung function data obtained at 1 year of age were collated From two cohorts of infants recruited into the UKOS and an RSV study, respectively. Setting: Infant pulmonary function laboratory. Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks). Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze. Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpIeth and tidal breathing parameters (TPTEF:TE). Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpIeth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHE:FRCpIeth were significantly associated with wheeze. Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.


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