TITLE

AIDS-Defining Illnesses: A Comparison Between Before and After Commencement of Highly Active Antiretroviral Therapy (HAART)

AUTHOR(S)
Ai Lian, Yvonne Lim; Lim Heng, Benedict Sim; Nissapatorn, Veeranoot; Lee, Christopher
PUB. DATE
September 2007
SOURCE
Current HIV Research;Sep2007, Vol. 5 Issue 5, p484
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Attempts to address the significant impact of HAART on medical variables on the Malaysian HIV/AIDS population have yet to be evaluated. This study aims to analyze the proportions of AIDS-defining illnesses (ADIs) before and after HAART. A retrospective study was carried out on 128 new cases of HIV infected patients who first commenced HAART in 2004 at the national HIV reference center. Before commencement of HAART, 76 clinical episodes of ADIs were recorded in 52 patients. Most common being pulmonary Mycobacterium tuberculosis (28.9%), PCP (27.6%) and disseminated and extrapulmonary Mycobacterium tuberculosis (11.8%). During HAART, 8 clinical episodes of ADIs were documented in 7 patients with a median time of onset of 10 weeks after initiation of HAART (range, 4-36 weeks). The median CD4 count at the time of the commencement of HAART for these patients was 11 cells/mm3. ADIs reported include PCP (2 episodes), disseminated and extrapulmonary Mycobacterium tuberculosis (2 episodes), extrapulmonary cryptococcosis (1 episode), esophageal candidiasis (1 episode), recurrent pneumonia (1 episode) and disseminated or extrapulmonary histoplasmosis (1 episode). Three (37.5%) of these occurred despite a reduction of viral load by at least 2 log10 and an increased in the CD4 cell count. In conclusion, ADIs can still present after the initiation of successful HAART especially in those with CD4 counts below 100 cells/mm3. In Malaysia, ADIs are the major causes of HIV/AIDS associated morbidity and mortality, thus increased awareness on the management of these illnesses is warranted especially in the months following HAART.
ACCESSION #
26369378

 

Related Articles

  • Extrapulmonary Tuberculosis - Its Management and Control. Maurya, Divya P.; Sultana, Yasmin; Sharma, Manju // Current Drug Therapy;Feb2010, Vol. 5 Issue 1, p67 

    Extrapulmonary tuberculosis refers to disease other than the lungs. The recent pandemic of Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) has changed the epidemiology of tuberculosis and has once again brought extrapulmonary tuberculosis into the limelight. Over...

  • What is TB disease?  // Tuberculosis: Getting Healthy, Staying Healthy;Jun2008, Issue 8, p9 

    The article provides an answer to a question of what is the nature of the tuberculosis (TB) disease.

  • How can my doctor tell if I have TB disease?  // Tuberculosis: Getting Healthy, Staying Healthy;Jun2008, Issue 8, p11 

    The article provides an answer to a question of how physicians will determine if the patient has tuberculosis (TB) disease.

  • Characterization of Mycobacterium tuberculosis Central Asian Strain1 using mycobacterial interspersed repetitive unit genotyping. Ali, Asho; Hasan, Zahra; Tanveer, Mahnaz; Siddiqui, Amna R.; Ghebremichael, Solomon; Kallenius, Gunilla; Hasan, Rumina // BMC Microbiology;2007, Vol. 7, p1 

    Background: The Central Asian Strain1 (CAS1) genogroup of Mycobacterium tuberculosis (MTB) is the most prevalent in Pakistan, India and Bangladesh. Mycobacterial interspersed repetitive units variable number tandem repeat (MIRU-VNTR) typing is a reliable and reproducible method for...

  • Genetic Diversity of the Mycobacterium tuberculosis Beijing Family Based on SNP and VNTR Typing Profiles in Asian Countries. Yih-Yuan Chen; Jia-Ru Chang; Wei-Feng Huang; Shu-Chen Kuo; Ih-Jen Su; Jun-Ren Sun; Tzong-Shi Chiueh; Tsi-Shu Huang; Yao-Shen Chen; Horng-Yunn Dou // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    The Mycobacterium tuberculosis (MTB) Beijing strain is highly virulent, drug resistant, and endemic over Asia. To explore the genetic diversity of this family in several different regions of eastern Asia, 338 Beijing strains collected in Taiwan (Republic of China) were analyzed by mycobacterial...

  • TB infection among staff at Tygerberg Academic Hospital, south Africa. Eshun-Wilson, I.; Zeier, M. D.; Taljaard, J. J.; Barnes, J. // Southern African Journal of Epidemiology & Infection;2008, Vol. 23 Issue 4, p17 

    This study was undertaken in order to characterise the occurrence, clinical spectrum and treatment outcomes of tuberculosis (TB) infection among staff at Tygerberg Academic Hospital over an 11-year period. A retrospective analysis was performed of all patients presenting to the occupational...

  • Pharmacotherapy for multidrug resistant tuberculosis. Chhabra, Naveen; Aseri, M. L.; Dixit, Ramakant; Gaur, S. // Journal of Pharmacology & Pharmacotherapeutics;Apr2012, Vol. 3 Issue 2, p98 

    The current global concern in the treatment of tuberculosis (TB) is the emergence of resistance to the two most potent drugs namely, isoniazid and rifampicin. Emergence of multidrug resistance tuberculosis (MDRTB) is now a health problem faced by most of the developing countries as well as...

  • UNA NUEVA GENERACIÓN DE VACUNAS ANTITUBERCULOSAS. J. Brennan, Michael // Vacunas: Prevención de enfermedades y protección de la salud;2004, p193 

    The article presents information on the development of effective vaccines for tuberculosis in the developing world. The need to develop vaccines for malaria and AIDS is one of the biggest challenges presently. It has been found that approximately 2 million HIV-negative individuals die because of...

  • TUBERCULOSE PULMONAR E OSTEOARTICULAR. Barcelos, Anabela; Coelho, Aida; Freitas, Filomena; Oliveira, Célia // Acta Reumatológica Portuguesa;2008, Vol. 33 Issue 1, p86 

    Tuberculosis is an important illness with an increasing prevalence in the last years in part due to AIDS. Considered primarily a pulmonary disease, tuberculosis can also affect almost any body system (nervous, genitourinary, and gastrointestinal as well as bones and joints) through...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics