TITLE

Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997-2003

AUTHOR(S)
Marras, Theodore K.; Chedore, Pamela; Ying, Alicia M.; Jamieson, Frances
PUB. DATE
August 2007
SOURCE
Thorax;Aug2007, Vol. 62 Issue 8, p661
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The prevalence of pulmonary non-tuberculous mycobacteria (NTM) infection is reportedly increasing. A study was undertaken of the ‘isolation prevalence’ of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM ‘disease’. Methods: In a retrospective cohort, the ‘isolation prevalence’ was studied by reviewing all positive NTM culture results from the Tuberculosis and Mycobacteriology Laboratory, Ministry of Health and Long-Term Care in Toronto from 1997 to 2003. This laboratory identifies at least 90% of NTM isolates in Ontario, Canada. Prevalence was compared between years using a negative binomial model. To study the frequency of ‘disease’ (defined by American Thoracic Society criteria), the records of patients who had an isolate in 2003 and had been assessed at our hospital were reviewed. Results: 22 247 pulmonary isolates were obtained from 10 231 patients. The ‘isolation prevalence’ of all species (excluding Mycobacterium gordonae) was 9.1/100 000 in 1997, rising to 14.1/100 000 by 2003 (p‼0.0001) with a mean annual increase of 8.4%. Similar increases were observed for individual species. 200 patients assessed at our institution were studied using American Thoracic Society criteria for ‘disease’. Microbiological criteria were fulfilled by 37%. Of patients with adequate data, 74% fulfilled clinical criteria, 77% fulfilled radiological criteria and 33% fulfilled all criteria. Conclusions: The ‘isolation prevalence’ of pulmonary NTM has significantly and rapidly increased in Ontario; a sizeable proportion of patients are likely to have ‘disease’.
ACCESSION #
26359978

 

Related Articles

  • Diagnostic performance of an enzyme-linked immunospot assay for interferon-γ in skeletal tuberculosis. Lai, C.-C.; Tan, C.-K.; Liu, W.-L.; Lin, S.-H.; Huang, Y.-T.; Liao, C.-H.; Hsueh, P.-R. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2011, Vol. 30 Issue 6, p767 

    The aim of this study was to evaluate the diagnostic performance of an enzyme-linked immunospot (ELISPOT) assay for interferon-γ in patients with suspected skeletal tuberculosis (TB). From March 2007 to June 2010, a total of 36 patients with suspected skeletal TB in a tertiary care hospital...

  • CLINICAL TRIAL DIGEST.  // Pulmonary Reviews;Aug2008, Vol. 13 Issue 8, p9 

    The article looks at key findings from recently published randomized clinical trials. A study published in the June 19, 2008 issue of "American Journal of Repiratory and Critical Care" concluded that activated protein C did not improve results in patients with acute lung injuries. A study...

  • Understanding wasted/ineffective efforts in mechanically ventilated COPD patients using the Campbell diagram. Vassilakopoulos, Theodoros // Intensive Care Medicine;Jul2008, Vol. 34 Issue 7, p1336 

    The article focuses on the study of wasted of ineffective efforts in mechanically ventilated chronic obstructive pulmonary disease (COPD) patients using the Campbell diagram. It explores the process of constructing the Campbell diagram. Several questions considered in the study are discussed,...

  • Biomarkers in COPD: time for a deep breath. Stockley, R. A. // Thorax;Aug2007, Vol. 62 Issue 8, p657 

    The author reflects on the issue concerning the significance of biomarkers in chronic obstructive pulmonary disease (COPD). He denotes that various specialists claim that biomarkers is associated with adverse effects in COPD patients such as inflammation. He asserts that biomarkers need to...

  • Short burst oxygen therapy after activities of daily living in the home in chronic obstructive pulmonary disease. Quantrill, S. J.; White, R.; Crawford, A.; Barry, J. S.; Batra, S.; Whyte, P.; Roberts, C. M. // Thorax;Aug2007, Vol. 62 Issue 8, p702 

    Background: Short burst oxygen therapy (SBOT) is widely prescribed in the UK with little evidence of benefit. A study was performed to examine whether SBOT benefits patients when undertaking normal activities at home among those who already use it. Methods: Twenty-two patients with chronic...

  • Buruli ulcer.  // Weekly Epidemiological Record;3/17/2000, Vol. 75 Issue 11, p85 

    Examines the epidemiology of Buruceli ulcer cause by Mycobacterium ulcerans. Treatment of the disease; Evaluation of the mode of transmission; Diagnosis of the disease process.

  • The Impact of Low Subcutaneous Fat in Patients with Nontuberculous Mycobacterial Lung Disease. Lee, Seok; Ryu, Yon; Lee, Jin; Chang, Jung; Shim, Sung // Lung;Jun2014, Vol. 192 Issue 3, p395 

    Background: Nontuberculous mycobacteria (NTM) are pathogens that cause chronic respiratory disease, even in immunocompetent patients. We hypothesized that low subcutaneous fat is a predisposing factor for NTM lung disease. Methods: Following a retrospective review of medical records from between...

  • Treatment outcome of tuberculosis patients at Gondar University Teaching Hospital, Northwest Ethiopia. A five - year retrospective study. Tessema, Belay; Muche, Abebe; Bekele, Assegedech; Reissig, Dieter; Emmrich, Frank; Sack, Ulrich // BMC Public Health;2009, Vol. 9 Issue 1, p371 

    Background: In Gondar University Teaching Hospital standardized tuberculosis prevention and control programme, incorporating Directly Observed Treatment, Short Course (DOTS) started in 2000. According to the proposal of World Health Organization (WHO), treatment outcome is an important indicator...

  • Reliability of Chest Wall Mobility and Its Correlation With Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease. Malaguti, Carla; .Rondelli, Rafaella R; de Souza, Leandra M.; Domingues, Marcia; Dal Corso, Simone // Respiratory Care;Dec2009, Vol. 54 Issue 12, p1703 

    BACKGROUND: Measurements of chest wall circumference are commonly used by physical therapists in clinical practice in order to determine chest wall mobility. However, the variability in the method for measuring this has not been reported previously among patients with chronic obstructive...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics