TITLE

Mendelian randomization as an instrumental variable approach to causal inference

AUTHOR(S)
Didelez, Vanessa; Sheehan, Nuala
PUB. DATE
August 2007
SOURCE
Statistical Methods in Medical Research;Aug2007, Vol. 16 Issue 4, p309
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In epidemiological research, the causal effect of a modifiable phenotype or exposure on a disease is often of public health interest. Randomized controlled trials to investigate this effect are not always possible and inferences based on observational data can be confounded. However, if we know of a gene closely linked to the phenotype without direct effect on the disease, it can often be reasonably assumed that the gene is not itself associated with any confounding factors—a phenomenon called Mendelian randomization. These properties define an instrumental variable and allow estimation of the causal effect, despite the confounding, under certain model restrictions. In this paper, we present a formal framework for causal inference based on Mendelian randomization and suggest using directed acyclic graphs to check model assumptions by visual inspection. This framework allows us to address limitations of the Mendelian randomization technique that have often been overlooked in the medical literature.
ACCESSION #
26322954

 

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