Merck Serono's Pergoveris Approved in EU

August 2007
BioPharm International;Aug2007, Vol. 20 Issue 8, p12
Trade Publication
The article announces that the European Commission has granted a marketing authorization for Merck Serono SA's Pergoveris. It is the first biotechnology product intended for the stimulation of follicular development in women with severe luteinizing hormone (LH) and follicle stimulating hormone (FSH) deficiency. Meanwhile, the decision of the commission applies to all 27 countries in the European Union (EU).


Related Articles

  • Reproductive endocrine effects of acute exposure to toluene in men and women. Luderer, U.; Morgan, M.S.; Brodkin, C.A.; Kalman, D.A.; Faustman, E.M. // Occupational & Environmental Medicine;Oct1999, Vol. 56 Issue 10, p657 

    Objectives: Despite observation of adverse reproductive effects of toluene, including alterations of serum gonadotropins (luteinising hormone (LH) and follicle stimulating hormone (FSH)) in humans, little is known of the mechanism of toxicity. The hypothesis was tested that toluene...

  • Differential actions of FSH and LH during folliculogenesis. Palermo, Roberto // Reproductive BioMedicine Online;Sep2007, Vol. 15 Issue 3, p326 

    In the gonadotrophin-dependent stage of follicular development, FSH- and LH-signalling pathways play an obligatory role in follicle differentiation, selection and survival. Under the effect of LH the theca-interstitial cell layer acts as an androgen producer. Thus, androgen diffusing into the...

  • A Model of Gonadotropin Regulation during the Menstrual Cycle in Women: Qualitative Features. Schlosser, Paul M. // Environmental Health Perspectives Supplements;Oct2000 Supplement 5, Vol. 108, p873 

    Develops a mechanistic, mathematical model of the human menstrual cycle that can be used to predict the effects of interactions between exogenous compounds and the sexual endocrine system in adult women. Luteinizing hormone; Follicle-stimulating hormone; Function of estrogen, progesterone and...

  • 50 years later�who would have thought�? Grudzinskas, Gedis // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Feb2011 Supplement, Vol. 22 Issue S1, preceding p73 

    The author discusses the advances in the development and therapeutic usage of gonadotropins. He states that such advances have been made possible using a multi-disciplinary approach to challenge not only the wisdom of the past but also the practices of in vitro fertilization (IVF) used by many...

  • The Integrated Gonadotrophin Test. Santner, Steven J.; Murray, Frederick T.; Davis, Bonnie; Santen, Richard J. // Annals of Internal Medicine;Oct78, Vol. 89 Issue 4, p512 

    Studies an alternative integrated gonadotrophin test in measuring luteinizing hormone and follicle-stimulating hormone. Drawback of gonadotrophin test; Advantage of the integration of serial gonadotrophin measurements in blood or urine; Reason for doing the test in prepubertal children.

  • Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain. Ballauff, A.; Ziegler, A.; Emons, G.; Sturm, G.; Blum, W.F.; Remschmidt, H.; Heberbrand, J. // Molecular Psychiatry;1999, Vol. 4 Issue 1, p71 

    Leptin plays an important role in reproductive function. In patients with acute anorexia nervosa, serum leptin levels have repeatedly been shown to be lower than in age-matched controls. We have previously hypothesized that the amenorrhea characteristic of anorexia nervosa is related to this low...

  • Decreased levels of testosterone and gonadotrophins in men with long-standing tetraplegia. Kostovski, E.; Iversen, P. O.; Birkeland, K.; Torjesen, P. A.; Hjeltnes, N. // Spinal Cord;Aug2008, Vol. 46 Issue 8, p559 

    Study Design:Blood samples were frequently collected during a 24-h period from six tetraplegic men. The results were compared with those of eight able-bodied controls.Objective:Previous studies have reported conflicting results regarding the plasma concentrations of testosterone, luteinizing...

  • Combination of T Gel and Transdermal NES Gel Decreases Gonadotropin Activity.  // Fertility Weekly;9/14/2009, p6 

    The article presents a study which examines the effects of transdermal nesteron (NES) gel alone or with testosterone (T) gel on gonadotropin suppression. The study concluded that NES had additive effect on the suppression of gonadotropins when combined with relatively high dose of T gel. It...

  • Channel Catfish Follicle-Stimulating Hormone and Luteinizing Hormone: Complementary DNA Cloning and Expression During Ovulation. Liu, Zhanjiang; Kim, Soonhag; Karsi, Attila // Marine Biotechnology;Nov2001, Vol. 3 Issue 6, p590 

    Gonadotropins are important regulators of reproduction. To develop molecular resources for production of recombinant gonadotropins, we have cloned and sequenced complementary DNA encoding the channel catfish (Ictalurus punctatus) follicle-stimulating hormone (FSH) and luteinizing hormone (LH),...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics