Late spontaneous remissions in severe adult autoimmune thrombocytopenia

Simanek, R.; Panzer, S.; Lechner, K.; Pabinger, I.
October 2007
Annals of Hematology;Oct2007, Vol. 86 Issue 10, p705
Academic Journal
We report on four cases (three women, one man, age at diagnosis 26–61 years) with severe autoimmune thrombocytopenia (AITP) who were refractory to initial steroid therapy ( n = 4), to subsequent splenectomy ( n = 2), azathioprine ( n = 1), and cyclosporine ( n = 1). Over years they received low-dose continuous or intermittent steroid therapy. After 6 to 31 years these patients achieved a “spontaneous” complete remission (CR) ( n = 3) or partial remission (PR) ( n = 1) unrelated to any specific second or third line treatment; CR/PR are sustained for 0.5+ to 9+ years. These data indicate that spontaneous remissions may occur in AITP even after a long duration of the disease.


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