TITLE

Late spontaneous remissions in severe adult autoimmune thrombocytopenia

AUTHOR(S)
Simanek, R.; Panzer, S.; Lechner, K.; Pabinger, I.
PUB. DATE
October 2007
SOURCE
Annals of Hematology;Oct2007, Vol. 86 Issue 10, p705
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We report on four cases (three women, one man, age at diagnosis 26–61 years) with severe autoimmune thrombocytopenia (AITP) who were refractory to initial steroid therapy ( n = 4), to subsequent splenectomy ( n = 2), azathioprine ( n = 1), and cyclosporine ( n = 1). Over years they received low-dose continuous or intermittent steroid therapy. After 6 to 31 years these patients achieved a “spontaneous” complete remission (CR) ( n = 3) or partial remission (PR) ( n = 1) unrelated to any specific second or third line treatment; CR/PR are sustained for 0.5+ to 9+ years. These data indicate that spontaneous remissions may occur in AITP even after a long duration of the disease.
ACCESSION #
26290167

 

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