TITLE

Assessing "occult" cervical cord damage in patients with neuropsychiatric systemic lupus erythematosus using diffusion tensor MRI

AUTHOR(S)
Benedetti, Beatrice; Rovaris, Marco; Judica, Elda; Donadoni, Giovanni; Ciboddo, Gianfranco; Filippi, Massimo
PUB. DATE
August 2007
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Aug2007, Vol. 78 Issue 8, p893
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Whereas focal and diffuse brain damage on conventional MRI is seen in patients with neuropsychiatric systemic lupus erythematosus (NSLE), the spinal cord seems to be rarely involved. Diffusion tensor (DT) MRI provides information on the patterns of tissue disruption of the central nervous system, which may go undetected by conventional MRI. Objective: To quantify the extent of otherwise ‘occult’ injury of the cervical cord in NSLE, and to improve our understanding of its nature. Subjects and methods: Conventional and DT MRI scans of the cervical cord and brain were acquired from 11 patients with NSLE and 10 healthy controls. Histograms of mean diffusivity (MD) and fractional anisotropy (FA) of the cervical cord and brain were analysed. Measures of cervical cord and brain atrophy and focal lesion loads were computed. Results: Only one patient had a single focal lesion of the cord whereas all had multiple brain lesions on conventional MRI scans. Cord and brain volumes did not differ between patients and controls. Mean peak height of the cervical cord MD histogram (p = 0.0001) and average brain FA (p = 0.001) were significantly lower in patients than in controls. Average cord MD was correlated with average brain MD (r = 0.69, p = 0.01) and FA(r = -0.81, p = 0.002). Conclusion: DI MRI shows mild and otherwise ‘occult’ cord damage in NSLE, which might be secondary to Wallerian degeneration of long tract fibres passing trough damaged areas of the brain.
ACCESSION #
26277391

 

Related Articles

  • New diffusion metrics for spondylotic myelopathy at an early clinical stage. Hori, Masaaki; Fukunaga, Issei; Masutani, Yoshitaka; Nakanishi, Atsushi; Shimoji, Keigo; Kamagata, Koji; Asahi, Koichi; Hamasaki, Nozomi; Suzuki, Yuriko; Aoki, Shigeki // European Radiology;Aug2012, Vol. 22 Issue 8, p1797 

    Objectives: To investigate the use of root mean square displacement (RMSD) and mean diffusional kurtosis (DK) metrics of q-space imaging data to estimate spinal cord compression in patients with early cervical spondylosis. Methods: We studied 50 consecutive patients at our institution (22 male,...

  • Brain Diffusion Changes in Patients Diagnosed with Alzheimer's Disease. Ito, Shoichi // Current Medical Imaging Reviews;2008, Vol. 4 Issue 4, p226 

    Alzheimer's disease is the most common neurodegenerative disease that features mainly memory impairment. The results of several pathologic and radiologic studies suggest that the brain damage in Alzheimer's disease extends well beyond the medial temporal lobes. The recent development of...

  • Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing–remitting multiple sclerosis. Sbardella, Emilia; Tona, F.; Petsas, N.; Upadhyay, N.; Piattella, M. C.; Filippini, N.; Prosperini, L.; Pozzilli, C.; Pantano, P. // Multiple Sclerosis Journal;Nov2015, Vol. 21 Issue 13, p1681 

    Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor imaging, and clinical impairments. Methods: Thirty...

  • Application of Advanced Neuroimaging Modalities in Pediatric Traumatic Brain Injury. Ashwal, Stephen; Tong, Karen A.; Ghosh, Nirmalya; Bartnik-Olson, Brenda; Holshouser, Barbara A. // Journal of Child Neurology;Dec2014, Vol. 29 Issue 12, p1704 

    Neuroimaging is commonly used for the assessment of children with traumatic brain injury and has greatly advanced how children are acutely evaluated. More recently, emphasis has focused on how advanced magnetic resonance imaging methods can detect subtler injuries that could relate to the...

  • Assessing the Correlation between Grey and White Matter Damage with Motor and Cognitive Impairment in Multiple Sclerosis Patients Sbardella, Emilia; Petsas, Nikolaos; Tona, Francesca; Prosperini, Luca; Raz, Eytan; Pace, Gianvito; Pozzilli, Carlo; Pantano, Patrizia // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    Background: Multiple sclerosis (MS) is characterized by demyelinating and degenerative processes within the central nervous system. Unlike conventional MRI,new advanced imaging techniques improve pathological specificity and better highlight the relationship between anatomical damage and...

  • Magnetic resonance imaging features of neuropsychiatric lupus. Mohan, Suyash; Verma, Ashish; Kumar, Sunil // Annals of Indian Academy of Neurology;2006, Vol. 9 Issue 4, p236 

    Central nervous system (CNS) involvement in patients of systemic lupus erythematosus (SLE) spans a wide spectrum of neurological and psychiatric features. In the absence of a diagnostic gold standard for neuropsychiatric lupus a range of investigations are employed to support the clinical...

  • Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement. Zivadinov, R; Shucard, JL; Hussein, S; Durfee, J; Cox, JL; Bergsland, N; Dwyer, MG; Benedict, RHB; Ambrus, J; Shucard, DW // Lupus;Jun2013, Vol. 22 Issue 7, p675 

    The article discusses the study which investigates non-conventional and conventional brain magnetic resonance imaging (MRI) findings in systemic lupus erythematosus (SLE) patients with diffuse neuropsychiatric involvement (dNPSLE) compared to healthy controls (HCs). The study uses 26 SLE...

  • Advances in MR imaging for cervical spondylotic myelopathy. Ellingson, Benjamin; Salamon, Noriko; Holly, Langston // European Spine Journal;Apr2015 Supplement, Vol. 24, p197 

    Purpose: To outline the pathogenesis of cervical spondylotic myelopathy (CSM), the correlative abnormalities observed on standard magnetic resonance imaging (MRI), the biological implications and current status of diffusion tensor imaging (DTI), and MR spectroscopy (MRS) as clinical tools, and...

  • Diffusion tensor imaging in spinal cord compression. Wei Wang; Wen Qin; Nanxin Hao; Yibin Wang; Genlin Zong // Acta Radiologica;Oct2012, Vol. 53 Issue 8, p921 

    Background: Although diffusion tensor imaging has been successfully applied in brain research for decades, several main difficulties have hindered its extended utilization in spinal cord imaging. Purpose: To assess the feasibility and clinical value of diffusion tensor imaging and tractography...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics