Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study

Defazio, G.; Martino, D.; Abbruzzese, G.; Girlanda, P.; Tinazzi, M.; Fabbrini, G.; Colosimo, C.; Aniello, M. S.; Avanzino, L.; Buccafusca, M.; Majorana, G.; Trompetto, C.; Livrea, P.; Berardelli, A.
August 2007
Journal of Neurology, Neurosurgery & Psychiatry;Aug2007, Vol. 78 Issue 8, p877
Academic Journal
Prior coffee and smoking habits were investigated in a multicentre case control study involving 166 patients presenting with primary late onset blepharospasm (BSP), 228 hospital control patients with primary hemifacial spasm and 187 population control subjects from five Italian centres. Information on age at disease onset, smoking and coffee drinking status at the reference age and average number of cups of coffee drunk/cigarettes smoked per day reached high and similar test-retest reproducibility in case and control patients. Unadjusted logistic regression analysis yielded a significant inverse association of prior coffee drinking and cigarette smoking with case status for the control groups. After adjustment for age, sex, referral centre, disease duration, years of schooling and ever coffee drinking/cigarette smoking, as appropriate, the smoking estimate lacked significance whereas the association of coffee intake and BSP did not (cases vs hospital control patients: OR 0.37 (95% CI 0.20 to 0.67); cases vs population control subjects: OR 0.44 (95% CI 0.23 to 0.85)). The strength of the inverse association between BSP and coffee intake tended to increase with the average number of cups drunk per day. There was a significant correlation between age of BSP onset and number of cups per day (adjusted regression coefficient 1.73; p = 0.001) whereas no correlation was found with number of packs of cigarettes per day. Coffee drinking may be inversely associated with the development of primary BSP and this association may partly depend on the amount consumed.


Related Articles

  • How to Diagnose and Relieve Periocular Spasm. Bernardino, C. Robert // Review of Ophthalmology;Aug2009, Vol. 16 Issue 8, p52 

    The article focuses on periocular spasms which is difficult to diagnose because of its unilateral and bilateral signs and symptoms. It discusses the need to examine and identify periocular spasms to avoid the formation of eyelid malpositions including Meige's syndrome and myokymia. It presents a...

  • Outcomes of surgical treatment for hemifacial spasm associated with the vertebral artery: severity of compression, indentation, and color change. Kim, Joo; Chung, Jong; Chang, Won; Chung, Sang; Chang, Jin // Acta Neurochirurgica;Mar2012, Vol. 154 Issue 3, p501 

    Object: The object of surgical treatment for hemifacial spasm (HFS) is the exclusion of pulsatile neurovascular compression of the root exit zone (REZ). However, spasm persists transiently or permanently in some cases even after complete decompression. In particular, we mainly experience these...

  • Atypical Microtia Correction with Multiple Z-Plasties. Günay, Galip K.; Örs, Safvet // Turkish Journal of Medical Sciences;2004, Vol. 34 Issue 1, p77 

    Presents a report on atypical microtia correction with multiple Z-plasties. Total or partial absence of the whole auricle or any of its components; Observation of facial palsy of the eyelid or lip; Presentation of a case of atypical microtia with normally shaped concha and lobule; Description...

  • Blepharospasm and hemifacial spasm: a protocol for titration of botulinum toxin dose to the individual patient and for the management of refractory cases. Ortisi, E.; Henderson, H. W. A.; Bunce, C.; Xing, W.; Collin, J. R. O. // Eye;Aug2006, Vol. 20 Issue 8, p916 

    PurposeTo evaluate a protocol for the treatment of facial dystonias.MethodA retrospective noncomparative interventional case series of all patients who attended a specialised tertiary referral clinic between January 2000 and January 2003. At the start of treatment, patients were seen and treated...

  • Botulinum toxin type B in blepharospasm and hemifacial spasm. Colosimo, C.; Chianese, M.; Giovannelli, M.; Contarino, M.F.; Bentivoglio, A.R. // Journal of Neurology, Neurosurgery & Psychiatry;May2003, Vol. 74 Issue 5, p687 

    Discusses a study on the clinical value of botulinum toxin type B in blepharospasm and hemifacial spasm. Role of botulinum neurotoxins in inhibiting the presynaptic release of acetylcholine causing a chemical denervation that results in sustained muscle weakness; Use of the neurotoxins in...

  • Posterior Fossa AVM Producing Hemifacial Spasm: A Case Report. Dujovny, Manuel; Osgood, Carroll P.; Faille, Ronald // Angiology;Jun1979, Vol. 30 Issue 6, p425 

    The article reports that hemifacial spasm is a disorder characterized by intermittent, chronic, unilateral contractions of the facial musculature. Although hemifacial spasm has been recognized us a diagnostic entity, the basic pathophysiology of this syndrome is not established. The association...

  • Humoral Immune Deficiency and Hemifacial Microsomia Seen in One Family. Mikhak, Zamaneh; Mulliken, John B.; Lee, John; Bonilla, Francisco A.; Kimonis, Virginia E. // Cleft Palate-Craniofacial Journal;Sep2009, Vol. 46 Issue 5, p477 

    We present a patient with hemifacial microsomia and immune deficiency. The patient is a 5-year-old with grade III microtia and Pruzansky type I right mandibular hypoplasia. She developed 25 pulmonary infections in 3 years, required hospitalization every 6 weeks to receive antibiotics, and...

  • Branchio-oto-renal Syndrome (BOR Syndrome, Melnick-Fraser Syndrome). Olney, Ann Haskins; Kolodziej, Peg // ENT: Ear, Nose & Throat Journal;Mar1998, Vol. 77 Issue 3, p172 

    Deals with the branco-oto-renal (BOR) syndrome, the association of branchial arch anomalies, hearing loss and renal anomalies, in children. What the branchial arch anomalies include; Chromosome where the syndrome lies.

  • Manifestaciones clínicas del espectro óculo aurículo vertebral. Véliz-Mendez, Sebastián; González-Escobar, Leonardo; Agurto-Veas, Pamela; Leiva-Villagra, Noemí // CES Odontología;2015, Vol. 28 Issue 1, p76 

    The Oculo Auriculo Vertebral spectrum corresponds to a heterogeneous and complex disorder that affects the development of structures derived from the first and second branchial arch. It has a variable commitment of maxillofacial structures , conditioning treatment for each patient to their...


Read the Article


Sign out of this library

Other Topics