TITLE

Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera

AUTHOR(S)
Verma, Susama; Cikurel, Katia; Koralnik, Igor J.; Morgello, Susan; Cunningham-Rundles, Charlotte; Weinstein, Zelig R.; Bergmann, Christine; Simpson, David M.
PUB. DATE
September 2007
SOURCE
Journal of Infectious Diseases;9/1/2007, Vol. 196 Issue 5, p709
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.
ACCESSION #
26240116

 

Related Articles

  • JAK2 Mutations in Polycythemia Vera – Molecular Mechanisms and Clinical Applications. Tefferi, Ayalew // New England Journal of Medicine;2/1/2007, Vol. 356 Issue 5, p444 

    The author presents his views on the molecular mechanisms and clinical applications of janus kinase 2 (JAK2) mutations in polycythemia vera. He presents a definition of JAK2 and mentions elements involved in JAK2 activation. He also talks about the viability of changing current diagnostic...

  • Polycythemia Vera. Murphy, Patrick A.; Conley, C. Lockard // JAMA: Journal of the American Medical Association;5/9/90, Vol. 263 Issue 18, p2481 

    Presents a case study of a patient with polycythemia vera. Medical history of the patient; Signs and symptoms of the disease; Nature of the disease; Methods of treatment.

  • THE ALLEN TEST IN POLYCYTHEMIA. Schwartz, Robert; Cooper, William M. // Angiology;Aug1952, Vol. 3 Issue 4, p317 

    A positive Allen test in patients with polycythemia is a reflection of the increased blood viscosity and retarded circulation, and does not necessarily indicate occlusive arterial disease in the wrists and hands. In such cases this finding would better be termed a ‘false-positive’...

  • Haematological response to naturally occurring disease in the western quoll ( Dasyurus geoffroyi). Clark, P.; Boardman, W. S. // Comparative Clinical Pathology;Jul2005, Vol. 13 Issue 4, p182 

    Haematological data from clinically ill western quolls was retrospectively analysed. A lymphocytosis was the most commonly encountered haematological abnormality, observed in 17/23 animals. In contrast, a neutrophilia was uncommon, present in only 1/23 cases. Two animals exhibited a...

  • Coinheritance of Chromosomes 3 and 11 in the Patients with Autosomal Recessive Polycythemia from Chuvachia. Vasserman, N. N.; Tverskaya, S. M.; Polyakov, A. V. // Russian Journal of Genetics;Sep2005, Vol. 41 Issue 9, p1035 

    Inheritance of chromosomes 3 and 11 in the families with Chuvash autosomal recessive polycythemia and in control group with no disease symptoms was examined using polymorphic dinucleotide markers D3S1597 and D3S1263, mapped to region 3p25, and D11S4111, D11S4127, and D11S1356, mapped to region...

  • Short and long term outcomes Following partial exchange transfusion in the polycythaemic newborn: a systematic review. Dempsey, E. M.; Barrington, K. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2006, Vol. 91 Issue 1, pF2 

    Background: Severe polycythaemia in the neonate may produce symptoms due to hyperviscosity and may be associated with serious complications. Partial exchange transfusion will reduce the packed cell volume. Objective: To determine whether partial exchange transfusion in term infants with...

  • Systematic review of the optimal fluid For dilutional exchange transfusion in neonatal polycythaemia. de Waal, K. A.; Baerts, W.; Offringa, M. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2006, Vol. 91 Issue 1, pF7 

    Objectives: Several studies have shown the efficacy of dilutional exchange transfusion (DET) in reducing haematocrit (Ht) and relieving clinical symptoms in neonatal polycythaemia. We conducted a systematic review to determine the efficacy of crystalloid versus colloid solutions used in DET in...

  • Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients. Ugo, Valerie; Tondeur, Sylvie; Menot, Marie-Laurence; Bonnin, Nadine; Le Gac, Gerald; Tonetti, Carole; Mansat-De Mas, Veronique; Lecucq, Lydie; Kiladjian, Jean-Jacques; Chomienne, Christine; Dosquet, Christine; Parquet, Nathalie; Darnige, Luc; Porneuf, Marc; Escoffre-Barbe, Martine; Giraudier, Stephane; Delabesse, Eric; Cassinat, Bruno // PLoS ONE;2010, Vol. 5 Issue 1, p1 

    Background: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F...

  • Polycythaemia Rubra Vera, Cerebral Ischaemia and Depression. Murray, Declan; Hodgson, Richard // British Journal of Psychiatry;Jun91, Vol. 158, p842 

    A patient with polycythaemia rubra vera complicated by severe psychotic depression is described. There have been no previous reports of polycythaemia rubra vera associated with psychiatric morbidity.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics