Combined Effects of Aldehyde Dehydrogenase Variants and Maternal Mitochondrial Genes on Alcohol Consumption

Israel, Yedy; Quintanilla, María E.; Sapag, Amalia; Tampier, Lutske
December 2006
Alcohol Research & Health;2006, Vol. 29 Issue 4, p284
Academic Journal
Two lines of rats bred to differ in their voluntary alcohol consumption—the alcohol-abstaining UChA rats and the alcohol-drinking UChB rats—differ in how effectively toxic acetaldehyde is removed during alcohol metabolism. UChB animals carry efficient variants of the aldehyde dehydrogenase 2 (ALDH2) genes and have active mitochondria, resulting in fast removal of acetaldehyde. UChA animals, in contrast, carry less efficient ALDH2 variants and less active mitochondria, which result in transient elevations of acetaldehyde levels after alcohol ingestion. Cross-breeding studies have demonstrated that the presence of active mitochondria inherited from UChB females can fully abolish the reduction of alcohol consumption associated with the presence of less efficient ALDH2 variants—a phenomenon known as epistasis. These and other findings suggest that mitochondrial activity during alcohol metabolism should be considered a new modulator of alcohol consumption not only in rats but also in other species, including humans.


Related Articles

  • A Promoter Polymorphism in the ALDH2 Gene Affects Its Basal and Acetaldehyde/Ethanol-Induced Gene Expression in Human Peripheral Blood Leukocytes and HepG2 Cells. Kimura, Yukiko; Nishimura, Fusae T.; Abe, Shuntaro; Fukunaga, Tatsushige; Tanii, Hideji; Saijoh, Kiyofumi // Alcohol & Alcoholism;May/Jun2009, Vol. 44 Issue 3, p261 

    Aims: To assess the effect of the -360G/A polymorphism in the promoter region of the human aldehyde dehydrogenase-2 (ALDH2) gene on its transcription, basal and acetaldehyde/ethanol-induced gene expression was examined by in vivo and in vitro experiments. Methods: Human peripheral blood...

  • Safety evaluation of ethanol based products and its influence on humans. Bennasir, Hassen A. H.; Sridhar, Shanmugam // Journal of Pharmacy Research;Nov2009, Vol. 2 Issue 11, p1732 

    Ethanol is almost used in all kinds of products which has direct contact to the human skin like hand disinfectants, cosmetics like hairsprays or mouthwashes, pharmaceutical preparations, and many household products.The first and foremost concerns of topical ethanol applications for public health...

  • Is habitual alcohol drinking associated with reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese? Lu, Yuquan; Morimoto, Kanehisa // Mutagenesis;Jul2009, Vol. 24 Issue 4, p303 

    Alcohol drinking-derived acetaldehyde is believed to cross-link DNA and induce sister chromatid exchanges in peripheral blood lymphocytes. However, little population data are available to illustrate effects of alcohol-derived acetaldehyde on DNA migration as assayed by the comet assay in...

  • What's your poison? Melton, Lisa // New Scientist;2/10/2007, Vol. 193 Issue 2590, p30 

    The article discusses acetaldehyde and its effects on the human body, particularly internal organs such as the brain, liver, and kidneys. Topics include an explanation of how acetaldehyde is converted to acetic acid, through an enzyme called aldehyde dehydrogenanses (ALDHs), the genetic link...

  • Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration. Maejima, Ryuhei; Iijima, Katsunori; Kaihovaara, Pertti; Hatta, Waku; Koike, Tomoyuki; Imatani, Akira; Shimosegawa, Tooru; Salaspuro, Mikko // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30–50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for...

  • Polymorphisms in Alcohol Metabolism Genes ADH1B and ALDH2, Alcohol Consumption and Colorectal Cancer. Crous-Bou, Marta; Rennert, Gad; Cuadras, Daniel; Salazar, Ramon; Cordero, David; Saltz Rennert, Hedy; Lejbkowicz, Flavio; Kopelovich, Levy; Monroe Lipkin, Steven; Bernard Gruber, Stephen; Moreno, Victor // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background: Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epidemiological risk factors for CRC included alcohol intake, which is mainly metabolized to acetaldehyde by alcohol dehydrogenase and further oxidized to acetate by aldehyde dehydrogenase; consequently, the role...

  • Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Visapää, J-P.; Götte, K.; Benesovo, M.; Li, J.; Homann, N.; Conradt, C.; Inoue, H.; Tisch, M.; Hörrmann, K.; Vakeväinen, S.; Salospuro, M.; Seitz, H. K. // Gut;Jun2004, Vol. 53 Issue 6, p871 

    Background: Chronic ethanol consumption is associated with an increased risk of upper aerodigestive tract cancer. As acetaldehyde seems to be a carcinogenic factor associated with chronic alcohol consumption, alcoholics with the alcohol dehydrogenase (ADH) 1C*1 allele seem to be particularly at...

  • Behavioral and biochemical evidence of the role of acetaldehyde in the motivational effects of ethanol. Peana, Alessandra T.; Acquas, Elio // Frontiers in Behavioral Neuroscience;Jul2013, Vol. 7, p1 

    Since Chevens' report, in the early 50's that his patients under treatment with the aldehyde dehydrogenase inhibitor, antabuse, could experience beneficial effects when drinking small volumes of alcoholic beverages, the role of acetaldehyde (ACD) in the effects of ethanol has been thoroughly...

  • Alcohol's Effect on the Development and Progression of Cancer. Homann, Nils; Seitz, Helmut K. // Nutrition in Clinical Care;Mar/Apr2000, Vol. 3 Issue 2, p83 

    In industrialized countries, alcohol intake is the major cause of cancer of the esophagus, oral cavity, and pharynx, it is also one of the most important risk factors for laryngeal and hepatocellular cancer. Epidemiologic studies are presently investigating a link between alcohol and an...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics