Alcohol Metabolism's Damaging Effects on the Cell

Koop, Dennis R.
December 2006
Alcohol Research & Health;2006, Vol. 29 Issue 4, p274
Academic Journal
Alcohol metabolism's various processes create harmful compounds that contribute to cell and tissue damage. In particular, the enzyme cytochrome P450 2E1 (CYP2E1) plays a role in creating a harmful condition known as oxidative stress. This condition is related to oxygen's ability to accept electrons and the subsequent highly reactive and harmful byproducts created by these chemical reactions. CYP2E1's use of oxygen in alcohol metabolism generates reactive oxygen species, ultimately leading to oxidative stress and tissue damage. INSET: NAMING AND CATEGORIZING THE P450 ENZYMES.


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