TITLE

Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: preliminary results of a prospective study

AUTHOR(S)
Díaz-González, Juan A.; Mayoral-Chávez, Miguel A.; Bohórquez, Paulina Leyva; De la Torre, Ma. del Pilar Gabriel; Hernández-Cruz, Pedro; Martínez-Cruz, Ruth; Pérez-Campos, Eduardo; Díaz-González, Juan A; Mayoral-Chávez, Miguel A; Bohórquez, Paulina Leyva; Hernández-Cruz, Pedro; Martínez-Cruz, Ruth; Pérez-Campos, Eduardo
PUB. DATE
September 2007
SOURCE
Indian Journal of Ophthalmology;Sep2007, Vol. 55 Issue 5, p349
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy.Aims: The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision.Materials and Methods: This was a prospective study on 20 patients with pterygium, divided in five stages, pre-surgery, early post-surgery (24h), late post-surgery (seven days), very late post-surgery (four weeks) and two months after the procedure. A drop of fluorescein-marked Con A (35 microg/mL) was instilled in the lower conjunctival eyelid sac and the eye was exposed to the light of a Wood's lamp for an average of five seconds.Results: Out of the 20 patients, eight patients were found to have fluorescent stretch marks over the scar corresponding to residual pterygial tissue at four weeks; two months after the procedure of re-surgery we observed no fluorescent remnants. All residual pterygia were confirmed through histochemistry studies.Conclusion: It was possible to detect remnants of pterygium in postoperative patients and recurrences in early pre-clinical stages through the visualization of fluorescent ConA bound to the pterygial surface.
ACCESSION #
26201075

 

Related Articles

  • Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin. Whaley-Connell, Adam; Habibi, Javad; Panfili, Zachary; Hayden, Melvin R.; Bagree, Sarika; Nistala, Ravi; Hyder, Safwan; Krueger, Bennett; DeMarco, Vincent; Pulakat, Lakshmi; Ferrario, Carlos M.; Parrish, Alan; Sowers, James R. // American Journal of Nephrology;2011, Vol. 34 Issue 2, p115 

    Background/aims: Angiotensin (Ang) II contributes to tubulointerstitial fibrosis. Recent data highlight mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling in tubulointerstitial fibrosis; however, the mechanisms remain unclear. Thereby, we investigated the role of Ang...

  • Activation of adherent vascular neutrophils in the lung during acute endotoxemia. Sunil, Vasanthi R.; Connor, Agnieszka J.; Peihong Zhou; Gordon, Marion K.; Laskin, Jeffrey D.; Laskin, Debra L.; Zhou, Peihong // Respiratory Research;2002, Vol. 3, p21 

    Background: Neutrophils constitute the first line of defense against invading microorganisms. Whereas these cells readily undergo apoptosis under homeostatic conditions, their survival is prolonged during inflammatory reactions and they become biochemically and functionally...

  • Enterocyte Response to Ischemia Is Dependent on Differentiation State Hinnebusch, Brian F.; Ma, Qing; Henderson, J. Welles; Siddique, Aleem; Archer, Sonia Y.; Hodin, Richard A. // Journal of Gastrointestinal Surgery;May2002, Vol. 6 Issue 3, p403 

    Enterocytes at the tips of microvilli are more sensitive to an ischemic insult than those cells residing in the crypts, an effect thought to be due to a relative lack of collateral flow. We speculated that this increased cellular sensitivity to ischemia might be an intrinsic feature of the cells...

  • Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after artificial rattlesnake envenomation in a porcine model. Hayes, William K.; Green, Steven M.; Cardwell, Michael D.; Bush, Sean P.; Hegewald, Kevin G.; Bush, S P; Hegewald, K G; Green, S M; Cardwell, M D; Hayes, W K // Wilderness & Environmental Medicine;Fall2000, Vol. 11 Issue 3, p180 

    Objectives: To determine if a commercially available negative-pressure venom extraction device (Extractor) reduces local tissue injury after artificial rattlesnake envenomation in a porcine model.Methods: We prospectively studied 10 pigs using a crossover design. After...

  • Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. Goetzl, Edward J.; Rosen, Hugh // Journal of Clinical Investigation;Dec2004, Vol. 114 Issue 11, p1531 

    T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity...

  • Nephrolithiasis: site of the initial solid phase. Bushinsky, David A. // Journal of Clinical Investigation;3/1/2003, Vol. 111 Issue 5, p602 

    Comments on an article which examined the site of the initial solid phase in nephrolithias. Discussion on the site of the initial solid phase; Mechanisms for stone formation; Description of an animal model of stone formation.

  • Influence of Ambient Stressors and Time Constraints on Diagnostic Accuracy of Borderline Pigmented Skin Lesions. Feci, Luca; Cevenini, Gabriele; Nami, Niccolò; Fagiolini, alberto; Perotti, Roberto; Miracco, Clelia; Fimiani, Michele; Rubegni, Pietro // Dermatology (10188665);Sep2015, Vol. 231 Issue 3, p269 

    Background: Health professionals are required to make complex decisions in dynamic contexts involving many variables and factors. Decisions are more difficult in the presence of uncertainty, urgency and high risk.Objective: To evaluate the effect of ambient stressors...

  • Effects of Fluoroquinolone-Based Antibacterial Ophthalmic Solutions on Corneal Wound Healing. Fukuda, Masamichi; Sasaki, Hiroshi // Journal of Ocular Pharmacology & Therapeutics;Nov2015, Vol. 31 Issue 9, p536 

    Purpose: To evaluate the effects of fluoroquinolone-based antibacterial ophthalmic solutions on cell proliferation in vitro and corneal wound healing in vivo.Methods: Staten's Serum institute rabbit corneal cells were exposed to phosphate-buffered saline, 1.5% and 0.5%...

  • Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions. Richter, Yoram; Groothuis, Adam; Seifert, Philip; Edelman, Elazer R. // Journal of Clinical Investigation;Jun2004, Vol. 113 Issue 11, p1607 

    Although arterial bifurcations are frequent sites for obstructive atherosclerotic lesions, the optimal approach to these lesions remains unresolved. Benchtop models of arterial bifurcations were analyzed for flow disturbances known to correlate with vascular disease. These models possess an...

  • Elastin fragments drive disease progression in a murine model of emphysema. Houghton, A. McGarry; Quintero, Pablo A.; Perkins, David L.; Kobayashi, Dale K.; Kelley, Diane G.; Marconcini, Luiz A.; Mecham, Robert P.; Senior, Robert M.; Shapiro, Steven D. // Journal of Clinical Investigation;Mar2006, Vol. 116 Issue 3, p753 

    Mice lacking macrophage elastase (matrix metalloproteinase-12, or MMP-12) were previously shown to be protected from the development of cigarette smoke-induced emphysema and from the accumulation of lung macrophages normally induced by chronic exposure to cigarette smoke. To determine the basis...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics