Vaginal mucosal vaccine for recurrent urinary tract infections

Gautam, Gagan; Khera, Rakesh
July 2007
Indian Journal of Urology;Jul-Sep2007, Vol. 23 Issue 3, p335
Academic Journal
The authors conducted a randomized double-blind placebo-controlled study to assess the clinical efficacy of vaginal placebo only (n = 25), primary immunization without boosters (n = 24) or primary immunization plus boosters (n = 26) using vaginal suppositories containing placebo or vaccine. Vaccine suppositories contained 10 strains of heat-killed uropathogenic bacteria (a total of 109 organisms from six strains of E. coli and one each of Proteus, Morganella, Klebsiella and E. fecalis in a polyethylene glycol base) and placebo suppositories had no vaccine organisms. Primary immunization consisted of three suppositories given at weekly intervals while boosters were given in three doses at monthly intervals after completion of the primary doses. All women were monitored for six months to record the number of infections and adverse events.


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