Edible vaccines: current status and future

Lal, P.; Ramachandran, V. G.; Goyal, R.; Sharma, R.
April 2007
Indian Journal of Medical Microbiology;Apr2007, Vol. 25 Issue 2, p93
Academic Journal
journal article
Edible vaccines hold great promise as a cost-effective, easy-to-administer, easy-to-store, fail-safe and socioculturally readily acceptable vaccine delivery system, especially for the poor developing countries. It involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. Introduced as a concept about a decade ago, it has become a reality today. A variety of delivery systems have been developed. Initially thought to be useful only for preventing infectious diseases, it has also found application in prevention of autoimmune diseases, birth control, cancer therapy, etc. Edible vaccines are currently being developed for a number of human and animal diseases. There is growing acceptance of transgenic crops in both industrial and developing countries. Resistance to genetically modified foods may affect the future of edible vaccines. They have passed the major hurdles in the path of an emerging vaccine technology. Various technical obstacles, regulatory and non-scientific challenges, though all seem surmountable, need to be overcome. This review attempts to discuss the current status and future of this new preventive modality.


Related Articles

  • EDIBLE VACCINES FROM GM CROPS: CURRENT STATUS AND FUTURE SCOPE. Doshi, V.; Rawal, H.; Mukherjee, S. // Journal of Pharmaceutical & Scientific Innovation;May/Jun2013, Vol. 2 Issue 3, p1 

    The idea of an edible vaccine is coming closer to reality as scientists have found a way to incorporate the protein gene with some antigen in some plants. The major hurdles in the path of an emerging vaccine technology are being overcome. In this context, genetically modified (GM) plants are...

  • How can plant genetic engineering contribute to cost-effective fish vaccine development for promoting sustainable aquaculture? Clarke, Jihong; Waheed, Mohammad; Lössl, Andreas; Martinussen, Inger; Daniell, Henry // Plant Molecular Biology;Sep2013, Vol. 83 Issue 1-2, p33 

    Aquaculture, the fastest growing food-producing sector, now accounts for nearly 50 % of the world's food fish (FAO in The state of world fisheries and aquaculture. FAO, Rome, ). The global aquaculture production of food fish reached 62.7 million tonnes in 2011 and is continuously increasing with...

  • Recent advances and safety issues of transgenic plant-derived vaccines. Guan, Zheng-jun; Guo, Bin; Huo, Yan-lin; Guan, Zheng-ping; Dai, Jia-kun; Wei, Ya-hui // Applied Microbiology & Biotechnology;Apr2013, Vol. 97 Issue 7, p2817 

    Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special...

  • Edible vaccines: not quite ready for prime time. Bonetta, Laura // Nature Medicine;Feb2002, Vol. 8 Issue 2, p94 

    Focuses on the experiments conducted by researchers in shifting their strategy for future tests of 'edible vaccines.' Costs involved in the shift from whole-fruit or vegetable vaccines to dry powder; Description of the process of engineering tomatoes or bananas to express vaccine; Advantages of...

  • Antiviral Agents, Vaccines, and Immunotherapies. Allen, D. // Annals of Internal Medicine;4/19/2005, Vol. 142 Issue 8, p686 

    The article focuses on the book "Antiviral Agents, Vaccines, and Immunotherapies," by S.K. Tyring. The book aims to enhance clinicians' and scientists' knowledge and understanding of current management strategies for viral diseases and the prospects of future advances. The book reviews recent...

  • Future needs and directions for Shigella vaccines.  // Weekly Epidemiological Record;2/10/2006, Vol. 81 Issue 6, p51 

    The article presents information on the future needs and directions for Shigella vaccines. In 1996, an international meeting was organized by the World Health Organization to consider the state of Shigella vaccines. The advances made since then in the development of Shigella vaccines are...

  • A Taste of Future Immunization.  // Drug Discovery & Development;Oct2002, Vol. 5 Issue 9, p36 

    Focuses on the development of edible vaccines against various diseases. Origin of the idea for developing edible vaccines; Reasons for the development of edible vaccines; Approach for developing safer genetically modified plants.

  • HPV Vaccination's Second Act: Promotion, Competition, and Compulsion. Schwartz, Jason L. // American Journal of Public Health;Oct2010, Vol. 100 Issue 10, p1841 

    Developments regarding human papillomavirus (HPV) vaccines will transform HPV vaccination in the United States while simultaneously raising several new policy and ethical concerns. Policymakers, vaccine manufacturers, and the public health community must now respond to the presence of competing...

  • Immunoprophylaxis of leprosy: current status and future prospects. Sehgal, V. N.; Sardana, K. // Indian Journal of Dermatology, Venereology & Leprology;Mar/Apr2007, Vol. 73 Issue 2, p71 

    The article presents an editorial on the current status and future prospects of the bacillus Calmette- Guérin (BCG) vaccine of leprosy. According to the authors, the matter continues to intrigue medical scientists, which the routine use of BCG vaccine has been postulated to benefit the...

  • Vaccines Against Drug Abuse. Shen, X Y; Orson, F M; Kosten, T R // Clinical Pharmacology & Therapeutics;Jan2012, Vol. 91 Issue 1, p60 

    The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics