TITLE

Increased pressure during retrograde cerebral perfusion provides better preservation of the Na+, K+-ATPase activity

AUTHOR(S)
Luojia Yang; Zhijun Li; Yanmin Yang; Zhu, Raymound; Summers, Randy; Deslauriers, Roxanne; Jian Ye
PUB. DATE
November 2006
SOURCE
Perfusion;Nov2006, Vol. 21 Issue 6, p319
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study was carried out to determine if increased perfusion pressure during retrograde cerebral perfusion (RCP) provides better preservation of the brain Na+, K+-ATPase activity. Twenty pigs were subjected to anesthesia alone (control group, n=5), hypothermic circulatory arrest (HCA) (HCA group, n=5), HCA+RCP at perfusion pressures of 24–29 mmHg (Low-pressure group, n=5), or HCA+RCP at perfusion pressures of 34–40 mmHg (High-pressure group, n=5). The brain was harvested for the measurement of tissue Na+, K+-ATPase activity. Relative to the control pigs (67.2±2.1%), significant impairment of Na+, K+-ATPase activity was observed in all three experimental groups (29.8±7.4% in HCA group, 33.5±2.9% in the Low-pressure group, and 52.0±1.8% in the High-pressure group, p <0.01). The best preservation of the enzyme, particularly in the cortex and cerebellum regions, was observed in the High-pressure group (p <0.01). In conclusion, HCA causes severe impairment of Na+, K+-ATPase activity, and increasing perfusion pressures from 24–29 to 34–40 mmHg during RCP significantly improves preservation of Na+, K+-ATPase activity, and the improvement of the protection varies in different regions of the brain.
ACCESSION #
26045016

 

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