TITLE

Iodine-promoted Prins-cyclization of ketones – A facile synthesis of spirocyclic-4-iodo-tetrahydropyrans and 5,6-dihydro-2H-pyrans

AUTHOR(S)
Yadav, J. S.; Reddy, B. V. Subba; Krishna, V. Hari; Swamy, T.; Kumar, G. G. K. S. Narayana
PUB. DATE
June 2007
SOURCE
Canadian Journal of Chemistry;Jun2007, Vol. 85 Issue 6, p412
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Homoallylic and homopropargylic alcohols undergo smooth coupling with ketones in the presence of molecular iodine at ambient temperature to produce spirocyclic-4-iodotetrahydropyrans and 5,6-dihydro-2H-pyrans, respectively, in high yields in a short reaction time with high selectivity. The use of molecular iodine makes this procedure quite simple, more convenient, and cost-effective.
ACCESSION #
26017828

 

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