TITLE

HLA related genetic risk for coeliac disease

AUTHOR(S)
Bourgey, Mathieu; Calcagno, Giuseppe; Unto, Nadia; Gennarelli, Daniela; Margaritte-Jeannin, Pafricia; Greco, Luigi; Limongelli, Maria Giovanna; Esposito, Oscar; Marano, Caterina; Troncone, Riccardo; Spampanato, Antonella; Clerget-Darpoux, Françoise; Sacchetti, Lucia
PUB. DATE
August 2007
SOURCE
Gut;Aug2007, Vol. 56 Issue 8, p1054
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8–12%). Aim and method: We evaluated the risk that sibs of children with CD will also develop CD. This cohort of 188 Italian families was composed of probands with CD, at least one sib and both parents. CD status was determined and human leucocyte antigen (HLA)-DQ genotyping performed in all family members. The study also used a dataset of Italian triads (127 probands and both their parents) also genotyped for HLA-DQ. Results: The overall risk that a sib of a CD patient will develop the disease was estimated at 10% in this sample. The risk estimate ranged from 0.1% to 29% when HLA-DQ information of the proband, parents and sib was considered. We found a negligible risk (lower than 1%) for 40% of the sibs of probands, a risk greater than 1% but less than 10% for 30%, and finally a high or very high risk (above 25%) in one-third of families. Conclusion: These results make it possible to provide more accurate information to parents with a child with CD about the real risk for another child. An antenatal estimate of the order of risk of CD is now possible. Specific follow-up can thus be offered for babies at high risk.
ACCESSION #
25972130

 

Related Articles

  • Age at Development of Type 1 Diabetes-and Celiac Disease-Associated Antibodies and Clinical Disease in Genetically Susceptible Children Observed From Birth. Simell, Satu; Hoppu, Sanna; Simell, Tuu; Ståhlberg, Marja-Riitta; Viander, Markku; Routi, Taina; Simell, Ville; Veijola, Riitta; Ilonen, Jorma; Hyöty, Heikki; Knip, Mikael; Simell, Olli // Diabetes Care;Apr2010, Vol. 33 Issue 4, p774 

    OBJECTIVE -- To compare the ages and sequence in which antibodies associated with type 1 diabetes and celiac disease appear and overt diseases develop in children with an HLA-conferred susceptibility to both diseases. RESEARCH DESIGN AND METHODS-- We observed 2,052 children carrying genetic...

  • Nationwide study of childhood celiac disease incidence over a 35-year period in Estonia. Ress, Krista; Luts, Katrin; Rägo, Tiina; Pisarev, Heti; Uibo, Oivi // European Journal of Pediatrics;Dec2012, Vol. 171 Issue 12, p1823 

    The aims of the study were to analyze the trends and characteristics of the incidence and clinical presentation of childhood celiac disease (CD) from 1976 to 2010 in Estonia. The study included all children up to 19 years of age diagnosed with small bowel biopsy proven CD. During a 35-year...

  • Mapping Disease-Susceptibility Genes in Admixed Populations Using Interval Principal Component Tests. Wen-Chung Lee; Yu-Hsiang Shu // Behavior Genetics;Sep2004, Vol. 34 Issue 5, p525 

    Family-based association approach for mapping disease-susceptibility genes of complex human diseases is a topical issue in genetic epidemiology. It is well known that admixture between genetically differentiated populations can result in high levels of linkage disequilibrium at loci separated...

  • Family-Based Association between Alzheimer's Disease and Variants in UBQLN1. Bertram, Lars; Hiltunen, Mikko; Parkinson, Michele; Ingelsson, Martin; Lange, Christoph; Ramasamy, Karunya; Mullin, Kristina; Menon, Rashmi; Sampson, Andrew J.; Hsiao, Monica Y.; Elliott, Kathryn J.; Velicelebi, Gonül; Moscarillo, Thomas; Hyman, Bradley T.; Wagner, Steven L.; Becker, K. David; Blacker, Deborah; Tanzi, Rudolph E. // New England Journal of Medicine;3/3/2005, Vol. 352 Issue 9, p884 

    Background: Recent analyses suggest that the known Alzheimer's disease genes account for less than half the genetic variance in this disease. The gene encoding ubiquilin 1 (UBQLN1) is one of several candidate genes for Alzheimer's disease located near a well-established linkage peak on...

  • Interaction between obesity-susceptibility loci in chromosome regions 2p25-p24 and 13q13-q21. Chuanhui Dong; Wei-Dong Li; Ding Li; Price, R. Arlen // European Journal of Human Genetics;Jan2005, Vol. 13 Issue 1, p102 

    One of the chief complexities of genetic influences on human obesity appears to be gene-gene interactions. Here, we employed model-free approaches to look for gene-gene interaction effects in human obesity using genome scan data from 260 European American families. We found consistent evidence...

  • Medicine may change our genes. Christakis, Nicholas A. // BMJ: British Medical Journal (International Edition);5/17/2008, Vol. 336 Issue 7653, p1101 

    The author reflects on advances which have been seen in medical genetics. He suggests that while the advances may allow medical technology to reshape the genome of individual patients and cure ailments by changing somatic genes, moral and ethical questions exist concerning their implementation....

  • Genome data, between 'know it all' and 'don't ask don't tell.'. BREINDL, ANETTE // Medical Device Daily;11/14/2012, Vol. 16 Issue 221, p1 

    The article focuses on a study published in the September 20, 2012 issue of "Genetics in Medicine" which developed a new method for identifying which gene variants need to be discussed with patients. 2,000 genetic variants implicated in Mendelian disorders were examined by Jonathan Berg and his...

  • EL PROBLEMA DE LA HERENCIA EN LA MEDICINA FRANCESA (1800-1846). VALLEJO, MAURO SEBASTIÁN // Llull: Revista de la Sociedad Espanola de Historia de las Cienci;2013, Vol. 36 Issue 77, p133 

    This article discusses the medical knowledge regarding the hereditary nature of human traits and diseases in 19th century France. The author examines contemporary accounts and articles published in medical dictionaries as well as theses from various medical institutions throughout the country....

  • Evidence for interaction between the TCO and NTM1 loci in familial non-medullary thyroid cancer. McKay, J.D.; Thompson, D.; Lesueur, F.; Stankov, K.; Pastore, A.; Watfah, C.; Strolz, S.; Riccabona, G.; Moncayo, R.; Romeo, G.; Goldgar, D.E. // Journal of Medical Genetics;Jun2004, Vol. 41 Issue 6, p407 

    Background: Familial non-medullary thyroid cancer (fNMTC) is a complex genetic disorder that is more aggressive than its sporadic counterpart. Thus far, three genetic loci have been implicated in susceptibility to fNMTC by linkage analysis. Methods: We used linkage analysis to test the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics