TITLE

Spectroscopic and electrochemical studies of cocaine–opioid interactions

AUTHOR(S)
Garrido, Jorge M. P. J.; Marques, M. Paula M.; Silva, Artur M. S.; Macedo, Tice R. A.; Oliveira-Brett, Ana M.; Borges, Fernanda
PUB. DATE
August 2007
SOURCE
Analytical & Bioanalytical Chemistry;Aug2007, Vol. 388 Issue 8, p1799
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine–opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug–drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine–morphine mixture (C–MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine’s methyl ester group. NMR studies conducted simultaneously also revealed C–MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine–morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine–heroin mixture. [Figure not available: see fulltext.]
ACCESSION #
25905067

 

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