TITLE

Maternal Antibody and Viral Factors in the Pathogenesis of Dengue Virus in Infants

AUTHOR(S)
Simmons, Cameron P.; Tran Nguyen Bich Chau; Tran Thi Thuy; Nguyen Minh Tuan; Dang Minh Hoang; Nguyen Thanh Thien; Le Bich Lien; Nguyen Thien Quy; Nguyen Trong Hieu; Tran Tinh Hien; McElnea, Catriona; Young, Paul; Whitehead, Steve; Nguyen Thanh Hung; Farrar, Jeremy
PUB. DATE
August 2007
SOURCE
Journal of Infectious Diseases;8/1/2007, Vol. 196 Issue 3, p416
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The pathogenesis of dengue in infants is poorly understood. We postulated that dengue severity in infants would be positively associated with markers of viral burden and that maternally derived, neutralizing antidengue antibody would have decayed before the age at which infants with dengue presented to the hospital. In 75 Vietnamese infants with primary dengue, we found significant heterogeneity in viremia and NS1 antigenemia at hospital presentation, and these factors were independent of disease grade or continuous measures of disease severity. Neutralizing antibody titers, predicted in each infant at the time of their illness, suggested that the majority of infants (65%) experienced dengue hemorrhagic fever when the maternally derived neutralizing antibody titer had declined to <1:20. Collectively, these data have important implications for dengue vaccine research because they suggest that viral burden may not solely explain severe dengue in infants and that neutralizing antibody is a reasonable but not absolute marker of protective immunity in infants.
ACCESSION #
25883204

 

Related Articles

  • Congenital and Neonatal Chikungunya in Colombia. Alvarado-Socarras, J. L.; Ocampo-González, M.; Vargas-Soler, J. A.; Rodriguez-Morales, A. J.; Franco-Paredes, C. // Journal of the Pediatric Infectious Diseases Society;Sep2016, Vol. 5 Issue 3, pc17 

    In Latin America and the Caribbean (LAC), chikungunya (CHIK) viral infection has emerged as a significant arboviral disease. This rapidly expanding vector-borne viral illness is associated with a substantial burden of disease in terms of acute illness and also in terms of long-term sequelae. In...

  • Genetic Determinants of Virulence in Pathogenic Lineage 2 West Nile Virus Strains. Botha, Elizabeth M.; Markotter, Wanda; Wolfaardt, Mariaan; Paweska, Janusz T.; Swanepoel, Robert; Palacios, Gustavio; Nel, Louis H.; Venter, Marietjie // Emerging Infectious Diseases;Feb2008, Vol. 14 Issue 2, p222 

    We determined complete genome sequences of lineage 2 West Nile virus (WNV) strains isolated from patients in South Africa who had mild or severe WNV infections. These strains had previously been shown to produce either highly or less neuroinvasive infection and induced genes similar to...

  • Insights into Arbovirus Evolution and Adaptation from Experimental Studies. Ciota, Alexander T.; Kramer, Laura D. // Viruses (1999-4915);Dec2010, Vol. 2 Issue 12, p2594 

    Arthropod-borne viruses (arboviruses) are maintained in nature by cycling between vertebrate hosts and haematophagous invertebrate vectors. These viruses are responsible for causing a significant public health burden throughout the world, with over 100 species having the capacity to cause human...

  • pathogen:. Huber, Jeffrey T.; Gillaspy, Mary L. // Encyclopedic Dictionary of AIDS-Related Terminology;2000, p173 

    A definition of the term "pathogen," which refers to any agent, especially a microorganism, capable of causing disease, is presented.

  • Intra-genotypic variation of predominant genotype II strains of dengue type-3 virus isolated during different epidemics in Thailand from 1973 to 2001. Zhang, Aimee; Chinnawirotpisan, Piyawan; Tang, Yuxin; Zhou, Yanfei; Lynch, Julia; Thomas, Stephen; Kalayanarooj, Siripen; Putnak, Robert; Zhang, Chunlin // Virus Genes;Apr2013, Vol. 46 Issue 2, p203 

    The prevalence of all four dengue virus (DENV) serotypes has increased dramatically in recent years in many tropical and sub-tropical countries accompanied by an increase in genetic diversity within each serotype. This expansion in genetic diversity is expected to give rise to viruses with...

  • Fluctuations at a Low Mean Temperature Accelerate Dengue Virus Transmission by Aedes aegypti. Carrington, Lauren B.; Armijos, M. Veronica; Lambrechts, Louis; Scott, Thomas W. // PLoS Neglected Tropical Diseases;Apr2013, Vol. 7 Issue 4, p1 

    Background: Environmental factors such as temperature can alter mosquito vector competence for arboviruses. Results from recent studies indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV)....

  • toxigenicity.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2344 

    A definition of the term "toxigenicity," which refers to the virulence of a toxin-producing pathogenic organism, is presented.

  • Fatal Disseminated Cryptococcus gattii Infection in New Mexico. Walraven, Carla J.; Gerstein, Wendy; Hardison, Sarah E.; Wormley, Floyd; Lockhart, Shawn R.; Harris, Julie R.; Fothergill, Annette; Wickes, Brian; Gober-Wilcox, Julie; Massie, Larry; Ku, T. S. Neil; Firacative, Carolina; Meyer, Wieland; Lee, Samuel A. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies...

  • Characterization and phylogenetic relationships of strains of Dengue type 1 virus from Costa Rica. Cerdas-Quesada, César-Alonso; Retana-Salazar, Axel P. // Revista de Biología Tropical;jun2007, Vol. 55 Issue 2, p365 

    Phylogenetic analysis of the envelope gene sequence (E) of three isolated Dengue virus type 1 (DEN-1) sequences from the Costa Rican 1993 epidemic was performed. All the strains fell into genotype V. Genotype V has grouped all the strains isolated from America, three strains from Africa and two...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics