TITLE

The Clinical Investigation of Securigera Securidaca (l.) Degen & Doerfler Seeds in Treatment of Type II Diabetic Patients: A Randomized, Double - Blind, Placebo - Controlled Study

AUTHOR(S)
Larijani, Bagher
PUB. DATE
June 2007
SOURCE
Diabetes;Jun2007 Supplement 1, Vol. 56, pA562
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Backgrounds and Aims: Securigera securidaca (L.) seeds is used by traditional herbalists for the treatment of diabetes in several parts of Iran. Clinical investigation of its efficacy and its toxicity in diabetic patients is of importance. Methods: A 2 - month randomized double blind clinical trail was conducted in 70 type II diabetic patients in two well - matched groups. One group (n=35) received 500 mg Securigera securidaca (L.) seeds capsule 3 times a day plus standard therapy, while the control group (n=35) received placebo plus standard therapy. The patients were visited monthly and glycosylated hemoglobin (HbA1c), fasting blood glucose, total cholesterol, LDL and HDL triglyceride, SGOT, SGPT, ALK, BUN, serum ceratinin levels were determined at the beginning and the end of the study after two months. Results: There was no significant change in HbA1c and fasting blood glucose level in Securigera securidaca (L.) seeds treated patients after two month as compared to beginning of the treatment and also as compared to placebo group. Serum lipid level was also not change significantly. The liver enzyme level and ceratinin level in blood was not changed significantly in Securigera securidaca (L.) seeds treated patients. No side effect was observed in all of patients in both groups. Conclusion: The results showed that the Securigera securidaca (L.) seeds treatment with known antidiabetic property in traditional herbal therapy has no beneficial effect on improving glycemic profile in type II diabetic patients. The use of this herbal medicine in the dose of 1500 mg in 3 divided doses showed no gastrointestinal symptom as well as liver and kindey abnormality during two months therapy. The long term efficacy and toxicity of it may be investigated in large multi center clinical study.
ACCESSION #
25822499

 

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