Low Concentration of Prostate Specific Antigen in Patients with Hypogonadotrophic Hypogonadism in Type 2 Diabetes

Dandona, Paresh; Upadhyay, Manish; Viswanathan, Prabhakar; Howard, Susan; Velazquez, Francisco; Chaudhuri, Ajay; Mohanty, Priya
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA558
Academic Journal
Prostate specific antigen (PSA) is secreted by the prostate gland and is a marker for prostatic carcinoma. In view of the frequent (33% of patients) occurrence of hypogonadotrophic hypogonadism (HH) in type 2 diabetes (T2D) and evidence that the prevalence of prostatic carcinoma in patients with T2D and the metabolic syndrome is lower than expected, we have investigated PSA concentrations in patients with T2D and HH. The mean concentration of PSA in normal subjects was 1.4 plusmn; 0.10 ng/ml (n = 114) while that in all patients with T2D was 0.79 ± 0.09 ng/ml. The mean PSA concentration in T2D patients with HH (calculated free testosterone < 6.5 ng/dl) was 0.75 ± 0.11 ng/ml (n = 49) while that in T2D patients with normal testosterone concentrations was 0.85 ± 0.15 ng/ml (n = 32). PSA in T2D patients was significantly lower (p< 0.001) than that in normal subjects. There were no significant differences between those with and without HH. Also, there were no correlations between PSA and testosterone levels. Thus, T2D is in itself a determinant of a low PSA while the low concentrations of T concentrations observed in HH patients do not exert a further effect on PSA. This may relate to a diminished mitotic/secretory activity of prostatic cells in T2D and may thus be associated with a diminished incidence of prostatic carcinoma in these patients. The mechanism(s) underlying this effect of T2D on PSA needs to be investigated further.


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