Exercise Training Response to Intramyocellular Lipid Content Is Not a Standard Response

Bajpeyi, Sudip; Tanner, Charles J.; Reed, Melissa; Molskness, Sara; Houmard, Joseph A.
June 2007
Diabetes;Jun2007 Supplement 1, Vol. 56, pA283
Academic Journal
Endurance-oriented exercise training enhances insulin action. However, the effect of such training on intramyocellular lipid (IMCL) content is not conclusive. Moreover, sedentary obese, and type 2 diabetic population have higher level of IMCL content compared to sedentary lean population and any chance due to exercise training may depend on this initial level. Hence, the purpose of this study was to determine if IMCL responses to endurance-oriented exercise training are primarily a function of the initial level IMCL rather than a standard response to exercise training. Eleven lean (two men, 9 women), 14 obese (one man, 13 women) and 9 type 2 diabetic (three men, 6 women) men and pre-menopausal women exercised on a bicycle ergometer at 70 - 75% VO[sub 2]max, for one hour each day for 10 consecutive days. Muscle biopsies from vastus lateralis muscle were taken before and after the exercise intervention. IMCL was quantified from image analysis of Oil Red O staining of muscle samples. Intramyocellular lipid (IMCL) content, expressed as a lipid accumulation index (LAI), in obese and type 2 diabetic subjects were about two fold higher compared to lean subjects (P < 0.001) prior to training. After 10 days of exercise training, lean and obese subjects did not show any significant change in IMCL content. However, type 2 diabetic subjects showed a significant decrease (about 35%) in IMCL content and normalized the IMCL level similar to lean subjects. This finding suggests that exercise training does not evoke a standard response in IMCL content but rather depends on the metabolic nature of the population studied.


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