TITLE

Effects of diallyl tetrasulfide on cadmiuminduced oxidative damage in the liver of rats

AUTHOR(S)
Murugavel, P.; Pari, L.
PUB. DATE
June 2007
SOURCE
Human & Experimental Toxicology;Jun2007, Vol. 26 Issue 6, p527
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The protective efficacy of diallyl tetrasulfide (DTS) from garlic on liver injury induced by cadmium (Cd) was investigated. In this study, Cd (3 mg/kg body weight) was administered subcutaneously for 3 weeks to induce toxicity. DTS was administered orally (10, 20 and 40 mg/kg body weight) for 3 weeks with subcutaneous (sc) injection of Cd. Cd-induced liver damage was evidenced from increased activities of serum hepatic enzymes, namely aspartate transaminase, alanine transaminase, alkaline phosphatase and lactate dehydrogenase, with significant elevation of lipid peroxidation indices (thiobarbituric acid reactive substances and hydroperoxides) and protein carbonyl groups in the liver. Rats subjected to Cd toxicity also showed a decline in the levels of total thiols, reduced glutathione (GSH), vitamin C and vitamin E, accompanied by an increased accumulation of Cd, and significantly decreased activities of superoxide dismutase, catalase (CAT), glutathione peroxidase, glutathione-S-transferase (GST), glutathione reductase, and glucose-6-phosphate dehydrogenase in the liver. Administration of DTS at 40 mg/kg body weight significantly normalised the activities of hepatic marker enzymes, compared to other doses of DTS (10 and 20 mg/kg body weight). In addition, DTS (40 mg/kg body weight) significantly reduced the accumulation of Cd and the level of lipid peroxidation, and restored the level of antioxidant defense in the liver. Histological studies also showed that administration of DTS to Cd-treated rats resulted in a marked improvement of hepatocytes morphology with mild portal inflammation. Our results suggest that DTS might play a vital role in protecting Cd-induced oxidative damage in the liver.
ACCESSION #
25817155

 

Related Articles

  • Inspired by garlic: insights on the chemistry of sulfenic acids and the radical-trapping antioxidant activity of organosulfur compounds. Chauvin, Jean-Philippe R.; Zielinski, Zosia A.M.; Pratt, Derek A. // Canadian Journal of Chemistry;2016, Vol. 94 Issue 1, p1 

    Organosulfur compounds have long been recognized as important antioxidants for the preservation of petroleum-derived products. It has also been suggested that the health benefits of garlic and related plant species can be ascribed to the radical-trapping antioxidant activity of some of their...

  • HEPATOPROTECTIVE EFFECT OF MANGIFERA-INDICA STEM BARK EXTRACTS ON PARACETAMOL-INDUCED OXIDATIVE STRESS IN ALBINO RATS. Omotayo, Mutiat Adetayo; Ogundare, Oyinlade Cecilia; Longe, Adeteju Oluwafunmilayo; Adenekan, Sunday // European Scientific Journal;8/31/2015, Vol. 11 Issue 24, p299 

    This study was conducted to evaluate the hepatoprotective activity of aqueous and ethanol extract of Mangifera-indica stem bark in paracetamolinduced liver injury in winstar albino rats. Aqueous and ethanolic extracts of M. indica stem bark at a dose of 200mg/kg were administered for 7 days to...

  • Effect of diallyldisulphide on an antioxidant enzyme system in Candida species. Yousuf, Snowber; Ahmad, Aijaz; Khan, Amber; Manzoor, Nikhat; Khan, Luqman Ahmad // Canadian Journal of Microbiology;Oct2010, Vol. 56 Issue 10, p816 

    This study was carried out to show the effect of diallyldisulphide (DADS), an important organosulphur compound found in garlic (Allium sativum), on antioxidant systems in Candida species. Changes in antioxidant metabolites and antioxidant activity in the presence of DADS were found in Candida...

  • The impact of allicin on lead-induced oxidative damage in selected organs of the common carp ( Cyprinus carpio). Shahsavani, Davar; Baghshani, Hasan; Aslani, Mohammad; Fatemi, Fatemeh // Comparative Clinical Pathology;Oct2012, Vol. 21 Issue 5, p769 

    Lead-induced oxidative stress contributes to the pathogenesis of lead poisoning. Considering the antioxidant properties of allicin, the objective of this study was to evaluate the efficacy of allicin in preventing lead-induced oxidative damage in the liver, kidney, brain, and gill of the common...

  • Curcumin Decreased Oxidative Stress, Inhibited NF-κB Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats. Samuhasaneeto, Suchittra; Thong-Ngam, Duangporn; Kulaputana, Onanong; Suyasunanont, Doungsamon; Klaikeaw, Naruemon // Journal of Biomedicine & Biotechnology;2009 Regular Issue, p1 

    To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks. A control group treated with distilled...

  • Hepatoprotective and antioxidant activities of grapeseeds against ethanol-induced oxidative stress in rats. Dogan, Abdulahad; Celik, Ismail // British Journal of Nutrition;2012, Vol. 107 Issue 1, p45 

    The present study was carried out to evaluate the hepatoprotective effect and antioxidant role of grape (Vitis vinifera L.) seeds (GS) against ethanol-induced oxidative stress. The hepatoprotective and antioxidant roles of the GS supplementation feed against ethanol-induced oxidative stress were...

  • The Effect of Experimental Thyroid Dysfunction on Markers of Oxidative Stress in Rat Pancreas. Sajadian, Mojtaba; Hashemi, Mohammad; Salimi, Saeedeh; Nakhaee, Alireza // Drug Development Research;Jun2016, Vol. 77 Issue 4, p199 

    The aim of the present study was to evaluate the effects of thyroid dysfunction on markers of oxidative stress in rat pancreas. Hypothyroidism and hyperthyroidism were, respectively, induced in rats via administration of propylthiouracil (PTU) and L-thyroxine sodium salt in drinking water for 45...

  • Comparison of Antioxidant Effects of Honey, Glibenclamide, Metformin, and Their Combinations in the Kidneys of Streptozotocin-Induced Diabetic Rats. Erejuwa, Omotayo Owomofoyon; Sulaiman, Siti Amrah; Ab Wahab, Mohd Suhaimi; Salam, Sirajudeen Kuttulebbai Nainamohammed; Md Salleh, Md Salzihan; Gurtu, Sunil // International Journal of Molecular Sciences;Jan2011, Vol. 12 Issue 1, p829 

    Hyperglycemia-induced increase in oxidative stress is implicated in diabetic complications. This study investigated the effect of metformin and/or glibenclamide in combination with honey on antioxidant enzymes and oxidative stress markers in the kidneys of streptozotocin (60 mg/kg;...

  • Nrf2-Inducing Anti-Oxidation Stress Response in the Rat Liver - New Beneficial Effect of Lansoprazole. Yamashita, Yasunobu; Ueyama, Takashi; Nishi, Toshio; Yamamoto, Yuta; Kawakoshi, Akatsuki; Sunami, Shogo; Iguchi, Mikitaka; Tamai, Hideyuki; Ueda, Kazuki; Ito, Takao; Tsuruo, Yoshihiro; Ichinose, Masao // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Lansoprazole is a potent anti-gastric ulcer drug that inhibits gastric proton pump activity. We identified a novel function for lansoprazole, as an inducer of anti-oxidative stress responses in the liver. Gastric administration of lansoprazole (10–100 mg/kg) to male Wistar rats produced a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics